{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:25:51Z","timestamp":1784258751590,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":5737,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was carried out to investigate the fate of the ultimobranchial contribution to the thyroid in man when the thyroid lobe is not fully descended. Thyroid abnormalities were recorded in 41 of 29000 autopsies at the London Hospital\u2014a prevalence of 1\u00b741\/1000. The 18 major abnormalities included four cases of lingual thyroid, in two of which cystic structures were noted in the neck in the region of the upper parathyroid. Three further cases of lingual thyroid with upper parathyroid cysts were collected from other sources.<\/jats:p><jats:p>The multilobulated cystic structures were up to 1\u00b75 cm in diameter and showed a variety of histologic features. In four cases there were glandular nodules of up to 1 mm across lying in the intercystic connective tissue. These nodules showed solid areas of irregularly distributed cells that stained positively for calcitonin and calcitonin gene\u2010related peptide, intermingled with, and sometimes apposed to, follicular structures that showed follicular cells and colloid that stained for thyroglobulin.<\/jats:p><jats:p>This study has provided conclusive evidence that the ultimobranchial body contributes both C cells and follicular cells to the thyroid in man, has documented the prevalence of congenital defects of thyroid development, and has described the human ultimobranchial gland as showing a wide developmental potential which may have implications in the histogenesis of thyroid neoplasia.<\/jats:p>","DOI":"10.1002\/path.1711590208","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T09:53:47Z","timestamp":1119434027000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["The ultimobranchial gland and congenital thyroid abnormalities in man"],"prefix":"10.1002","volume":"159","author":[{"given":"E. D.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E.","family":"Toyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. R.","family":"Harach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","article-title":"The embryology of the human thyroid gland including ultimobranchial body and others related","volume":"44","author":"Sugiyama S","year":"1971","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01945893"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90813-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.158.3803.924"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284951"},{"key":"e_1_2_1_7_2","first-page":"249","article-title":"Ultrastructural observations on cytodifferentiation of parafollicular cells in the human fetal thyroid","volume":"25","author":"Chan AS","year":"1971","journal-title":"Lab Invest"},{"key":"e_1_2_1_8_2","first-page":"2857","article-title":"Demonstration de I'origine neurale des cellules a calcitonine du corps ultimobranchial chez I'embryon de poulet","volume":"270","author":"Le Douarin N","year":"1970","journal-title":"CR Acad Sci (Paris)"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001330304"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237970"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200201"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225578"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000146024"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000146373"},{"key":"e_1_2_1_15_2","first-page":"355","article-title":"Congenital thyroid abnormalities and the ultimobranchial gland in man","volume":"132","author":"Williams ED","year":"1980","journal-title":"J Pathol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.34.9.1000"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80133-X"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000242547"},{"key":"e_1_2_1_19_2","first-page":"1","volume-title":"Handbuch der Speziellen Pathologischen Anatomie und Histologie","author":"Wegelin C","year":"1926"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700480119"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091890307"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092000409"},{"key":"e_1_2_1_23_2","first-page":"95","article-title":"Laterally situated neck cysts derived from the embryological remnants of thyroid development","volume":"12","author":"Parham DM","year":"1988","journal-title":"Histopathology"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233921"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1985.tb02435.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.19.2.103"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2071::AID-CNCR2820440618>3.0.CO;2-O"},{"key":"e_1_2_1_28_2","first-page":"178","article-title":"Pleomorphic adenoma of the thyroid containing salivary gland cells with pseudocartilage and myoepithelial cells","volume":"59","author":"Lange MJ","year":"1974","journal-title":"Int Surg"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197609)38:3<1323::AID-CNCR2820380335>3.0.CO;2-B"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800515)45:10<2564::AID-CNCR2820451015>3.0.CO;2-3"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198409000-00010"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198507000-00007"},{"key":"e_1_2_1_33_2","first-page":"1157","article-title":"Primary mucinproducing adenosquamous carcinoma of the thyroid gland","volume":"37","author":"Mizukami Y","year":"1987","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198901000-00006"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3702.1464"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109742"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711590208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711590208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:24:33Z","timestamp":1761053073000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711590208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1002\/path.1711590208"],"URL":"https:\/\/doi.org\/10.1002\/path.1711590208","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]},"assertion":[{"value":"1989-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1989-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}