{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:14:01Z","timestamp":1789913641384,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":5676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of over 400 well\u2010documented biopsies of mucocutaneous leishmaniasis was evaluated to elucidate the histological processes associated with the elimination of parasites, and their correlation with the course of the disease. Non\u2010specific inflammation was the most frequent and least effective response; its onset might be delayed, and in this event particularly the incidence of metastasis from skin to mucosa was high. Lysis of parasite\u2010laden macrophages appeared to be the basic mechanism of parasite reduction, even when it was not overt. When it was acute the onset was usually rapid, and though it resulted in much tissue destruction the prognosis was generally better and mucosal metastasis rare. Lysis and non\u2010specific inflammation both led to the formation of a post\u2010necrotic type of granuloma, but reversion of the process was almost as common as progression. Ultimately a tuberculoid granuloma evolved and proceeded to resolution. In about 5 per cent of cases, macrophage activation appeared to bring about early resolution; neither reversion nor mucosal metastasis was seen.<\/jats:p>","DOI":"10.1002\/path.1711590406","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:27:01Z","timestamp":1119436021000},"page":"293-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Histological analysis and the pathogenesis of mucocutaneous leishmaniasis"],"prefix":"10.1002","volume":"159","author":[{"given":"Dennis S.","family":"Ridley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albino V.","family":"De Magalhaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90243-9"},{"key":"e_1_2_1_3_2","first-page":"131","article-title":"Apparent glucantime failure in five patients with mucocutaneous leishmaniasis","volume":"83","author":"Rocha RAA","year":"1980","journal-title":"J Trop Med Hyg"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1973.22.696"},{"key":"e_1_2_1_5_2","first-page":"195","article-title":"Diagnostico parasitologico e immunologico de leishmaniasis tegumentaria americana","volume":"89","author":"Cuba CAC","year":"1980","journal-title":"Bol Of Sanit Panam"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(79)90199-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711410109"},{"key":"e_1_2_1_8_2","first-page":"79","article-title":"Macrophage\u2010parasite interaction in the lesions of cutaneous leishmaniasis","volume":"123","author":"Ridley MJ","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90174-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651987000400005"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651986000500003"},{"key":"e_1_2_1_12_2","first-page":"601","article-title":"Histological studies of the elimination of Leishmania enriettii from skin lesions in the guinea\u2010pig","volume":"61","author":"Monroy A","year":"1980","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_1_13_2","first-page":"137","article-title":"Immunopathology of experimental leishmaniasis","volume":"114","author":"Andrade ZA","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_1_14_2","first-page":"327","article-title":"Cutaneous leishmaniasis: immune complex formation and necrosis in the acute phase","volume":"65","author":"Ridley MJ","year":"1984","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_1_15_2","first-page":"380","article-title":"Immunohistological investigations in chronic leishmaniasis in Saudi Arabia","volume":"38","author":"Veress B","year":"1986","journal-title":"Trop Geogr Med"},{"key":"e_1_2_1_16_2","first-page":"15","article-title":"Borderline cutaneous leishmaniasis. 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