{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:43:21Z","timestamp":1761093801019,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":5676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To examine whether endotoxaemia contributes to the development of bile infarction and whether obstructive jaundice enhances endotoxin hepatotoxicity, the present study was undertaken in rats. The development of bile infarction and the elevation of serum transaminase activities in rats following ligation of the common bile duct were not prevented by administration of polymyxin B, neomycin, or lactulose, which have anti\u2010endotoxin properties. Moreover, the morphological and functional changes in obstructive jaundice were not enhanced by administration of endotoxin. These data indicate that endotoxaemia does not contribute to the development of bile infarction. On the other hand, the administration of a small dose of endotoxin to rats with biliary obstruction\u2010a dose which does not induce abnormalities of liver function tests or any morphological changes in the liver in non\u2010jaundiced rats\u2010led to focal hepatocellular coagulative necrosis and elevation of serum transaminase levels. These data indicate that endotoxin\u2010induced hepatic injury is potentiated in obstructive jaundice.<\/jats:p>","DOI":"10.1002\/path.1711590412","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:27:01Z","timestamp":1119436021000},"page":"335-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Endotoxaemia and hepatic injury in obstructive jaundice"],"prefix":"10.1002","volume":"159","author":[{"given":"Yuro","family":"Shibayama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"741","article-title":"Fibrinogen in liver disease","volume":"109","author":"Wardle EN","year":"1974","journal-title":"Am J Surg"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80729-3"},{"key":"e_1_2_1_4_2","first-page":"519","article-title":"Bile salts, endotoxin and renal function in obstructive jaundice","volume":"165","author":"Cahill CJ","year":"1987","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6049.1415"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700350512"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700830218"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1962.tb01235.x"},{"key":"e_1_2_1_9_2","first-page":"55","article-title":"Liver blood flow studies during and after various periods of total biliary obstruction in the dog","volume":"135","author":"Aronsen KF","year":"1969","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_10_2","first-page":"731","article-title":"Influence of common bile duct ligation on hepatic blood flow","volume":"36","author":"Sakoda K","year":"1970","journal-title":"Am Surg"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6025.1568"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5854.640"},{"key":"e_1_2_1_13_2","first-page":"356","article-title":"Lactulose\u2010a drug with antiendotoxin effect","volume":"27","author":"Liehr H","year":"1980","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800731003"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.80.1.66"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.92.4.815-819.1966"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.100.2.1128-1130.1969"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(87)80048-1"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711510206"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103141"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.112.6.1157"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711510412"},{"key":"e_1_2_1_23_2","first-page":"1127","article-title":"A study on the mechanism of acute hepatic necrosis following partial resection of the liver","volume":"37","author":"Shirai M","year":"1987","journal-title":"Acta Pathol Jpn"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711590412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711590412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:50:34Z","timestamp":1761051034000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711590412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,12]]}},"alternative-id":["10.1002\/path.1711590412"],"URL":"https:\/\/doi.org\/10.1002\/path.1711590412","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1989,12]]},"assertion":[{"value":"1989-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1989-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}