{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:07:49Z","timestamp":1761163669912,"version":"build-2065373602"},"reference-count":85,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":5554,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We have previously shown the depletion of cutaneous calcitonin gene\u2010related peptide (CGRP)\u2010 and substance P\u2010comaining nerves in human leprosy. The aims of this study were to investigate the temporal effects of leprosy on nerves in skin and spinal cord. Tissues were taken from nude mice, 6 and 12 months after inoculation of\n                    <jats:italic>Mycobacterium leprae<\/jats:italic>\n                    into the hind footpads, and from age\u2010matched controls. Sections were immunostained with antisera to substance P or CGRP. After 6 months of infection, substance P\u2010 and CGRP\u2010immunoreactive nerves were reduced in skin from all body areas; by 12 months, the reduction was substantially greater. In the spinal cord, sensory fibres immunoreactive for substance P had decreased compared with controls at 6 and 12 months [by 60 per cent (0.022 mm\n                    <jats:sup>2<\/jats:sup>\n                    ) and 80 per cent (0.048 mm\n                    <jats:sup>2<\/jats:sup>\n                    ), respectively,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001], as with CGRP [30 per cent (0.018 mm\n                    <jats:sup>2<\/jats:sup>\n                    ) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.02) and 40 percent (0.028 mm\n                    <jats:sup>2<\/jats:sup>\n                    ) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01), respectively]. CGRP immunoreactivity was completely absent in motor neurones after 12 months of infection. Loss of CGRP\u2010 and substance P\u2010immunoreactive fibres in skin and spinal cord, and CGRP in motor neurones is in accord with impaired pain sensation and muscle weakness in leprosy.\n                  <\/jats:p>","DOI":"10.1002\/path.1711600411","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:02:24Z","timestamp":1119434544000},"page":"335-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Time\u2010related decrease of substance P and CGRP in central and peripheral projections of sensory neurones in\n                    <i>Mycobacterium leprae<\/i>\n                    infected nude mice: A model for lepromatous leprosy in man"],"prefix":"10.1002","volume":"160","author":[{"given":"S. S.","family":"Karanth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. R.","family":"Springall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Royston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K.","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Polak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"89","article-title":"Nerve involvement in leprosy; pathogenesis and significance","volume":"16","author":"Iyer CGS","year":"1986","journal-title":"Neurol India"},{"key":"e_1_2_1_3_2","first-page":"251","article-title":"Pathology of peripheral nerve lesions in lepromatous leprosy","volume":"39","author":"Job CK","year":"1971","journal-title":"Int J Lepr"},{"key":"e_1_2_1_4_2","first-page":"47","article-title":"Ultrestructure of lepromatous nerves; neural pathogenesis in leprosy","volume":"41","author":"Dastur DK","year":"1973","journal-title":"Int J Lepr"},{"key":"e_1_2_1_5_2","first-page":"51","article-title":"Perineural changes in untreated leprosy","volume":"46","author":"Pearson JMH","year":"1975","journal-title":"Lepr Rev"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711040202"},{"key":"e_1_2_1_7_2","first-page":"26","article-title":"Study of early nerve lesions in mice infected with","volume":"180","author":"Mehta LN","year":"1976","journal-title":"M. Ieprae. Lepr India"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.7.3081"},{"key":"e_1_2_1_9_2","first-page":"360","volume-title":"Immunecytochemistry: Modern Methods and Applications","author":"Gibson SJ","year":"1986"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1983.tb01738.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221851"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/284515a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90101-X"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.07.030184.001521"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(86)90158-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(87)90075-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-12-03101.1984"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218323"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218210"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01260994"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90694-5"},{"key":"e_1_2_1_22_2","first-page":"51","volume-title":"Neuropeptides and Neural Transmission","author":"Lembeck F","year":"1980"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/286155a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90986-5"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0031-6997(25)06575-5","volume":"35","author":"Pernow B","year":"1983","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-06-01653.1985"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720738.ch14"},{"key":"e_1_2_1_28_2","first-page":"323","article-title":"Antinociception induced in rats by intrathecal administration of antiserum against calcitoningene\u2010reiated peptide","volume":"51","author":"Kuraishi Y","year":"1988","journal-title":"Neuroscience"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91310-8"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90074-6"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1985.tb11107.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90195-3"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90374-4"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/315061a0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90073-2"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/339701a0"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/323809a0"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90257-0"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb04836.x"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902660304"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.19.7366"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(85)90211-4"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(85)90248-4"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90505-0"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00224131"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90930-X"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688468"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90123-4"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/295061a0"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(89)90057-0"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711570104"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/262399a0"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00506570"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90346-1"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00220022"},{"key":"e_1_2_1_56_2","first-page":"897","article-title":"Schwann cell changes in lepromatous leprosy","volume":"63","author":"Job CK","year":"1975","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_57_2","first-page":"324","article-title":"Degeneration and regeneration of unmyelinated fibres in experimental leprous neuropathy","volume":"49","author":"Shetty VP","year":"1981","journal-title":"Int J Lepr"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.111.12.1571"},{"key":"e_1_2_1_59_2","first-page":"78","article-title":"Histopathological study of clinically normal appearing skin in lepromatous leprosy","volume":"51","author":"Bedi TR","year":"1979","journal-title":"Lepr India"},{"key":"e_1_2_1_60_2","first-page":"40","article-title":"Histological profile in apparently normal skin of leprosy patients","volume":"54","author":"Sakuntala R","year":"1982","journal-title":"Lepr India"},{"key":"e_1_2_1_61_2","first-page":"281","article-title":"Study of apparently normal skin in leprosy","volume":"40","author":"Ganapathi R","year":"1972","journal-title":"Int J Lepr Other Mycobac Dis"},{"key":"e_1_2_1_62_2","first-page":"205","volume-title":"Leprosy in Theory and Practice","author":"Lumsden CE","year":"1964"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-3-1-194"},{"key":"e_1_2_1_64_2","first-page":"221","article-title":"Serum demyelinating factors and adjuvant activity of Mycobacterium leprae; possible cause of early nerve damage in leprosy","volume":"57","author":"Shetty VP","year":"1985","journal-title":"Lepr Rev"},{"key":"e_1_2_1_65_2","first-page":"157","article-title":"Neural auto\u2010antibodies in leprosy","volume":"46","author":"Wright DJM","year":"1975","journal-title":"Lepr Rev"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1967.sp008227"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1969.32.6.1025"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.242075"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01989781"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91335-7"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/270741a0"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.228392"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)90237-8"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90012-X"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90371-8"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90064-4"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1977.40.6.1325"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901860202"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(82)91120-4"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91861-2"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965027"},{"key":"e_1_2_1_82_2","first-page":"356A","article-title":"Chronic pain, inflammation and muscle dysfunction induce marked neuro peptide changes in the spinal cord","volume":"158","author":"Kar S","year":"1989","journal-title":"J Pathol"},{"key":"e_1_2_1_83_2","first-page":"327","article-title":"Neuritis and paralysis in leprosy","volume":"54","author":"Goodwin CS","year":"1968","journal-title":"Physiotherapy"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90440-4"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90877-9"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3363373"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711600411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711600411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:34:32Z","timestamp":1761068072000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711600411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["10.1002\/path.1711600411"],"URL":"https:\/\/doi.org\/10.1002\/path.1711600411","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1990,4]]},"assertion":[{"value":"1989-11-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1989-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}