{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:41:05Z","timestamp":1761061265996,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":5249,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A group of Wistar albino rats was injected subcutaneously with monocrotaline to induce vasoconstrictive hypertensive pulmonary vascular disease characterized by medial hypertrophy of small pulmonary arteries, the appearance of muscular pulmonary arterial vessels of arteriolar dimensions (less than 20 \u03bcm in diameter), and exudative changes in the lung parenchyma. The vascular abnormalities were quantified by measuring the percentage medial thickness of small pulmonary arteries, the number of muscular pulmonary arterial vessels below 20 \u03bcm in diameter per cm<jats:sup>2<\/jats:sup> of lung section and by determining the smallest arterial vessels in each case showing muscularity. A second group of rats was born in a decompression chamber and kept in hypobaric hypoxia for a month of the neonatal period, developing hypoxic hypertensive pulmonary vascular disease as a consequence. The animals in this group were allowed to recover in room air for a period of 3 months and were then injected with the same dose of monocrotaline as that given to the first group. The rats previously exposed to hypoxia exhibited an exaggerated response to the alkaloid, showing in particular many more small muscular pulmonary arterial vessels which were of a smaller diameter than those found in the eupoxic rats treated with the alkaloid. The experiment demonstrates that perinatal hypoxia exaggerates the effects of agents inducing vasoconstrictive pulmonary hypertension with a shift of the segment of the pulmonary arterial tree involved to the periphery as in hypoxia. Reports of a similar phenomenon are noted as occurring in babies born at high altitude, spending their infancy there and subsequently developing primary pulmonary hypertension later in life.<\/jats:p>","DOI":"10.1002\/path.1711630209","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T10:13:46Z","timestamp":1119435226000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Influence of hypobaric hypoxia in infancy on the subsequent development of vasoconstrictive pulmonary vascular disease in the Wistar albino rat"],"prefix":"10.1002","volume":"163","author":[{"given":"Anthony","family":"Caslin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Heath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000398180"},{"key":"e_1_2_1_3_2","first-page":"353","article-title":"Pulmonary arteries and veins in experimental hypoxia","volume":"93","author":"Dingemans KP","year":"1978","journal-title":"Am J Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","unstructured":"FultonRM HutchinsonEC JonesAM. Ventricular weight in cardiac hypertrophy.Br Heart J1952;413\u2013420.","DOI":"10.1136\/hrt.14.3.413"},{"volume-title":"Crotalaria spectabilis, the pulmonary hypertension plant","year":"1969","author":"Kay JM","key":"e_1_2_1_5_2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01054.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711120104"},{"key":"e_1_2_1_8_2","first-page":"65","article-title":"A pathophysiological study of 10 cases of hypoxic cor pulmonale","volume":"66","author":"Wilkinson M","year":"1988","journal-title":"Q J Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01161.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.22.2.176"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700920216"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711020205"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711580408"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711530210"},{"key":"e_1_2_1_15_2","first-page":"505","article-title":"Normal postnatal development of the media of the rat hilar pulmonary artery and its remodeling by chronic hypoxia","volume":"46","author":"Meyrick B","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_1_16_2","first-page":"603","article-title":"Endothelial and sabintimal changes in rat hilar pulmonary artery during recovery from hypoxia","volume":"42","author":"Meyrick B","year":"1980","journal-title":"Lab Invest"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711550213"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1988.tb01915.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(63)80389-3"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711630209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711630209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:25:50Z","timestamp":1761060350000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711630209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,2]]}},"alternative-id":["10.1002\/path.1711630209"],"URL":"https:\/\/doi.org\/10.1002\/path.1711630209","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1991,2]]},"assertion":[{"value":"1990-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1990-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}