{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:48:50Z","timestamp":1761094130266,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4883,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A panel of monoclonal antibodies specific for TcR V gene families was used to study TcR V region expression in 28 cases of malignant and reactive T\u2010cell expansions including four cases of mixed cellularity Hodgkin's disease (HD) and five reactive cases. TcR V\u03b25 gene products were represented in three cases of lymphoblastic malignancy (V\u03b25.1, V\u03b25.2) and two cases of peripheral T\u2010cell lymphoma (PTCL) (V\u03b25.1). In the PTCL cases, the expanded family was found in the absence of clonal TcR gene rearrangements and in one of these cases with Ig JH and Ck clonal gene rearrangements consistent with the presence of a phenotypically and histologically undetectable clonal B\u2010cell population. In a third PTCL case not investigated for genotype, the TCR V<jats:italic>a<\/jats:italic>12 family was overrepresented. Expanded TcR V<jats:italic>a<\/jats:italic>2 and V\u03b25.1 families were identified in HD and V\u03b28 and V\u03b25.2\/V\u03b25.3 families in a reactive lymph node and CD3 and CD8\u2010positive blood lymphocytosis respectively. Further study of PTCL and related entities are needed to establish whether expanded TcR families are common in those cases that fail to exhibit clonal TcR gene rearrangement.<\/jats:p>","DOI":"10.1002\/path.1711660205","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T14:14:13Z","timestamp":1119449653000},"page":"109-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["T\u2010Cell receptor variable (V) gene usage by lymphoid populations in T\u2010cell lymphoma"],"prefix":"10.1002","volume":"166","author":[{"given":"John L.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy M.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl H.","family":"Janson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"344A","article-title":"The use of anti\u2010clonotypic T cell receptor antibodies in the diagnosis of T cell lymphoma","volume":"155","author":"Salter DM","year":"1988","journal-title":"J Pathol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711580104"},{"key":"e_1_2_1_4_2","first-page":"17","article-title":"Cutaneous T cell lymphoma cells employ a restricted range of T cell antigen receptor variable region genes","volume":"136","author":"Jack AS","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.297"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.9.995"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.138.5.1502"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.142.4.1395"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.2.741"},{"key":"e_1_2_1_10_2","first-page":"A486","article-title":"Monoclonal antibodies specific to human T cell antigen receptor V\u2010beta gene products","volume":"3","author":"Tian WT","year":"1989","journal-title":"FASEB J"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.20.7888"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.3.1000"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00204993"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312293092601"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(89)90174-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2382141"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.3.659"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.8.1776.1776"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/345344a0"},{"key":"e_1_2_1_20_2","unstructured":"GrunewaldJ JansonCH EklundA et al.Restricted Va2.3 gene usage by CD4 + lymphocytes in bronchoalveolar lavage (BAL) fluid from sarcoidosis patients correlates with HLA\u2010DR3. Submitted for publication."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114634"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210342"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711660205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711660205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:49:35Z","timestamp":1761058175000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711660205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1002\/path.1711660205"],"URL":"https:\/\/doi.org\/10.1002\/path.1711660205","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1992,2]]},"assertion":[{"value":"1991-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1991-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}