{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:29:17Z","timestamp":1770985757124,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4854,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>P53 is a tumour suppressor gene, located in the short arm of chromosome 17, which encodes for a nuclear protein involved in the control of cellular growth, regulating the entry of the cell into the S\u2010phase. P53 mutations have been identified in a progressively increasing number of human malignancies. Nuclear p53 protein is usually present in non\u2010tumour cells in minute concentrations, due to its short half\u2010life. In contrast, tumours with p53 mRNA mutations show a higher nuclear protein concentration, detectable by immunohistological techniques, due to stabilization by complexing with other proteins such as heat\u2010shock protein or wild\u2010type p53 protein.<\/jats:p><jats:p>Leveis of nuclear p53 protein detected by immunohistochemistry with the monoclonal antibody PAb 1801 were measured with the aid of an image analysis system in 83 non\u2010Hodgkin's lymphomas (NHLs) and 13 cases of Hodgkin's disease, as well as in 14 cases of normal thymus, reactive tonsils, and lymphadenitis. High levels of p53 protein (&gt;5 per cent of the cells) were present only in high\u2010grade lymphomas (in the proportion 13\/55), with a peak incidence in Burkitt's lymphoma (5\/8 cases). Lower levels (&lt;5 per cent) of p53 protein were detected in low\u2010grade B\u2010 and T\u2010cell lymphomas, as well as in most of the cases of Hodgkin's disease, where p53 protein was selectively present in Hodgkin and Reed\u2010Sternberg cells. In 5\/14 reactive tonsils or lymph nodes, occasional p53\u2010positive cells were identified.<\/jats:p><jats:p>These results suggest a relationship between levels of p53 protein and the aggressiveness of NHL. The sporadic presence of p53\u2010positive cells in human reactive tissues suggests that its expression could depend not only on mutation, but also on stabilization of the protein through complexing with other nuclear proteins. It is not known if this mechanism is also responsible for the p53 nuclear accumulation in high\u2010grade lymphomas.<\/jats:p>","DOI":"10.1002\/path.1711660305","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T14:15:58Z","timestamp":1119449758000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["P53 protein expression in lymphomas and reactive lymphoid tissue"],"prefix":"10.1002","volume":"166","author":[{"given":"Raquel","family":"Villuendas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Piris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan 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