{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:03:35Z","timestamp":1770469415534,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4609,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the\n                    <jats:italic>erbB\u2010<\/jats:italic>\n                    2 receptor. A third member of this receptor family,\n                    <jats:italic>erbB\u2010<\/jats:italic>\n                    3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the\n                    <jats:italic>erbB\u2010<\/jats:italic>\n                    3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the\n                    <jats:italic>erbB\u2010<\/jats:italic>\n                    3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.\n                  <\/jats:p>","DOI":"10.1002\/path.1711680305","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:12:11Z","timestamp":1119442331000},"page":"269-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["The\n                    <i>erbB\u20103<\/i>\n                    Gene in human pancreatic cancer"],"prefix":"10.1002","volume":"168","author":[{"given":"Nicholas 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