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FUN\u20101 reacts with pokeweed mitogen\u2010activated B lymphocytes and monocytes of peripheral blood, but not with unstimulated lymphocytes or granulocytes. It also reacts with large lymphoid cells in germinal centres, Epstein\u2013Barr virus\u2010transformed B cell lines, large B\u2010cell lymphomas, Ki\u20101\u2010positive anaplastic largecell lymphomas, and Reed\u2013Sternberg cells of Hodgkin's disease, but not with Concanavalin A\u2010activated T cells, acute lymphoblastic leukaemias, T\u2010cell lymphomas, or low\u2010grade B\u2010cell leukaemias. These findings indicate that FUN\u20101 recognizes a previously unreported B\u2010cell activation antigen. This MoAb appears to be useful for the study of maturation and differentiation in the B\u2010cell lineage as well as for the immunohistochemical diagnosis of B\u2010cell lymphomas and Hodgkin's disease.<\/jats:p>","DOI":"10.1002\/path.1711690306","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:17:23Z","timestamp":1119442643000},"page":"309-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A novel monoclonal antibody (FUN\u20101) identifies an activation antigen in cells of the B\u2010cell lineage and Reed\u2014Sternberg cells"],"prefix":"10.1002","volume":"169","author":[{"given":"Yoshihiro","family":"Nozawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Wachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.3.1516"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.612"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.127.1.347"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90239-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.5.3007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.128.2.823"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.4.2228"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.4.1208"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.156.319"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/256495a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/22.12.1077"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820690527"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_16_2","first-page":"1311","article-title":"Report of the nomenclature committee","volume":"26","author":"Lukes RJ","year":"1966","journal-title":"Cancer Res"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<483::AID-CNCR2820610313>3.0.CO;2-L"},{"key":"e_1_2_1_18_2","first-page":"31","article-title":"Four distinct antigen systems on human thymus and T cells defined by monoclonal antibodies: immunohistological and immunochemical studies","volume":"53","author":"Ishii Y","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(88)80088-8"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.1.1.1"},{"key":"e_1_2_1_22_2","first-page":"49","article-title":"B. cell lymphoma: histogenesis, proliferation and extension","volume":"79","author":"Wakasa H","year":"1990","journal-title":"Trans Soc Pathol Jpn"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110005"},{"key":"e_1_2_1_24_2","first-page":"109","volume-title":"Leucocyte Typing IV","author":"D\u00f6rken B","year":"1989"},{"key":"e_1_2_1_25_2","first-page":"457","article-title":"Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma","volume":"56","author":"Timens W","year":"1986","journal-title":"Lab Invest"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/86.3.292"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890601)63:11<2083::AID-CNCR2820631102>3.0.CO;2-U"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900070202"},{"key":"e_1_2_1_29_2","first-page":"370","article-title":"Lectin receptors as markers of lymphoma cells. 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