{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:04:35Z","timestamp":1772899475985,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4458,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraepithelial lymphocyte migration is a biological process frequently observed in skin and tonsil. Using immuno\u2010histochemistry, we have studied the molecular bases of this process in seven skin biopsies involved by mycosis fungoides (MF) and in 12 tonsils, four involved by B\u2010chronic lymphocytic leukaemia (B\u2010CLL) and eight by lymphoid follicular hyperplasia (LH). In the skin, intraepidermal T\u2010lymphocyte infiltration was associated with narrowing and fragmentation of the basement membrane, as shown by an anti\u2010collagen type IV antibody. Immunostaining of serial sections with an anti\u2010collagenase type IV antibody revealed that collagenase type IV was localized in the upper dermis and Strictly co\u2010distributed with collagen type IV, suggesting that enzymatic digestion played a role in the alterations of the basement membrane. Further migration through the epidermis was mediated by expression on keratinocytes of intercellular adhesion molecule\u20101 (ICAM\u20101) and of leukocyte\u2010function associated antigen\u20101 (LFA\u20101) on infiltrating lymphocytes. In the tonsil, intraepithelial infiltration was mediated by the expression of vascular cell adhesion molecule\u20101 (VCAM\u20101) by epithelial cells and of very late antigen\u20104 (VLA\u20104) by infiltrating lymphocytes. Further intraepithelial lymphocyte migration was then established, as already shown in the skin, by ICAM\u20101\/LFA\u20101 interaction. Lymphocyte recruitment from the systemic circulation was studied using antibodies directed against endothelial leukocyte adhesion molecule\u20101 (ELAM\u20101), ICAM\u20101, and VCAM\u20101. These adhesion molecules were highly expressed by blood vessels in the upper dermis of MF and the percentage of ELAM\u20101 +\/VCAM\u20101 + vessels was significantly higher than that observed in tonsils. Our data suggest that distinct molecular mechanisms are used by lymphocytes in intraepithelial migration in the skin and in tonsils.<\/jats:p>","DOI":"10.1002\/path.1711690405","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:18:03Z","timestamp":1119442683000},"page":"413-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Molecular mechanisms involved in intraepithelial lymphocyte migration: A comparative study in skin and tonsil"],"prefix":"10.1002","volume":"169","author":[{"given":"Stefania","family":"Uccini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi P.","family":"Ruco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Monardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria Lesnoni","family":"La Parola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Decio","family":"Cerimele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo D.","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-197901010-00002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12722441"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70090-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb00050.x"},{"key":"e_1_2_1_6_2","first-page":"1","article-title":"Evidence for involvement of lymphocyte function\u2010associated antigen 1 in T cell migration to epidermis","volume":"46","author":"Shiohara T","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.1.245"},{"key":"e_1_2_1_8_2","first-page":"121","article-title":"Tumor necrosis factor and interferon\u2010\u03b3 induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of","volume":"135","author":"Munro JM","year":"1989","journal-title":"Papio anubis. Am J Pathol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.4.1323"},{"key":"e_1_2_1_10_2","first-page":"585","article-title":"Immunohistochemical distribution of type IV collagenase in normal, benign and malignant breast tissue","volume":"136","author":"Monteagudo C","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_11_2","first-page":"647","article-title":"Evaluation of hepatocellular carcinoma aggressiveness by a panel of extracellular matrix antigens","volume":"138","author":"Grigioni WF","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90104-8"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9238"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.4.1369"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90775-7"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.2.661"},{"key":"e_1_2_1_17_2","first-page":"1163","article-title":"Cytokine production (IL\u20101 alpha, IL\u20101 beta and TNF alpha) and endothelial cell activation (ELAM\u20101 and HLA\u2010DR) in reactive lymphadenitis, Hodgkin's disease, and in non\u2010Hodgkin's lymphomas. An immunocytochemical study","volume":"137","author":"Ruco LP","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)60831-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90661-W"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/284067a0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6190230"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35946-X"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04515.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12285689"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1697696"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.6.1297"},{"key":"e_1_2_1_27_2","first-page":"1337","article-title":"Expression and cell distribution of the intercellular adhesion molecule, vascular cell adhesion molecule, endothelial leukocyte adhesion molecule and endothelial cell adhesion molecule (CD31) in reactive human lymph nodes and in Hodgkin's disease","volume":"140","author":"Ruco LP","year":"1992","journal-title":"Am J Palhol"},{"key":"e_1_2_1_28_2","first-page":"385","article-title":"Vascular and nonvascular expression of INCAM\u2010110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues","volume":"138","author":"Rice GE","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_1_29_2","unstructured":"RucoLP ParadisoP PittiglioM et al.Tissue distribution of VLA\u20101\/6 and VLA\u2010ligands in the normal thymus and in thymoma.Am J Pathol(in press)."},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.901"},{"key":"e_1_2_1_31_2","unstructured":"RosenGD La ChanceR SanesJ DeanDC.A role for VLA\u20104\/ VCAM\u20101 in muscle differentiation.J Cell Biochem Suppl16F1992;189(Abstract)."},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90115-S"},{"key":"e_1_2_1_33_2","first-page":"1297","article-title":"HML\u20101 antigen on mucosa\u2010associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta7 subunit","volume":"139","author":"Micklem KJ","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/349796a0"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.139.5.1557"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.6.1461"},{"key":"e_1_2_1_37_2","first-page":"1053","article-title":"A unique phenotype of skin\u2010associated lymphocytes in humans. Preferential expression of the HECA\u2010452 epitope by benign and malignant cells at cutaneous sites","volume":"136","author":"Picker LJ","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_38_2","first-page":"221","volume-title":"Vascular endothelium: interaction with circulating cells","author":"Ruco LP","year":"1991"},{"key":"e_1_2_1_39_2","first-page":"313","article-title":"Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues","volume":"64","author":"Kock AE","year":"1991","journal-title":"Lab Invest"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711690405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711690405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:43:52Z","timestamp":1761057832000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711690405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["10.1002\/path.1711690405"],"URL":"https:\/\/doi.org\/10.1002\/path.1711690405","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4]]},"assertion":[{"value":"1992-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1992-10-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}