{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:03:23Z","timestamp":1770822203937,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4458,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoreactivity for the tumour suppressor gene product p53 is commonly found in many different human malignancies and few premalignant lesions. Data on cervical neoplasms, however, are still lacking. We retrospectively investigated p53 immunoreactivity in 92 lesions of the uterine cervix, including 44 cases of chronic cervicitis, 29 squamous intraepithelial lesions (SILs), and 19 invasive carcinomas. p53 immunoreactivity confined to the basal cell layer, was detected in 74 per cent of cases showing chronic cervicitis and in all cases with low\u2010grade SILs. Conversely, suprabasal and\/or diffuse p53 immunoreactivity was exclusively demonstrated in 25 per cent of high\u2010grade SILs and in 74 per cent of invasive carcinomas. The results of this investigation document a high prevalence of p53\u2010immunoreactive malignant tumours of the uterine cervix. In high\u2010grade SILs, p53\u2010immunoreactive cells paralleled the height of involvement by dysplastic changes within the squamous epithelium. A prolonged half\u2010life of the protein is the most likely explanation for the occurrence of p53 immunoreactivity in neoplastic cells. The unexpected finding of p53\u2010immunoreactive cells in inflammatory lesions, though possibly related to an increased proliferation rate of the basal cell compartment, requires further study and underlines the need for a careful approach to p53 immunocytochemistry.<\/jats:p>","DOI":"10.1002\/path.1711690407","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:18:03Z","timestamp":1119442683000},"page":"425-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["p53 Immunoreactivity in inflammatory and neoplastic diseases of the uterine cervix"],"prefix":"10.1002","volume":"169","author":[{"given":"Silvano","family":"Bosari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Roncalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Viale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Coggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.1.1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)61001-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.10.2851"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90801-B"},{"key":"e_1_2_1_6_2","first-page":"893","article-title":"Genetic and immunochemical analysis of mutant p53 in human cancer cell lines","volume":"5","author":"Bartek J","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_1_7_2","first-page":"1699","article-title":"Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies","volume":"6","author":"Bartek J","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_8_2","first-page":"145","article-title":"Widespread p53 overexpression in human malignant tumors. 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