{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:27:42Z","timestamp":1761290862053,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4428,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study we investigated immunohistochemically the expression of p53 and c\u2010<jats:italic>erb<\/jats:italic>B\u20102 proteins in 30 gall bladder adenocarcinomas, one carcinoma <jats:italic>in situ<\/jats:italic>, eight gall bladder epithelial dysplasias, and four cases of chronic cholecystitis. p53 expression could be found in 14 (47 per cent) adenocarcinomas and in two out of eight epithelial dysplasias. There were significantly more p53\u2010positive grade II\u2010III tumours than grade I tumours (<jats:italic>P<\/jats:italic>=0.032 according to Fisher's exact probability test). c\u2010<jats:italic>erb<\/jats:italic>B\u20102 expression was found in three (10 per cent) adenocarcinomas, but all dysplasias were c\u2010<jats:italic>erb<\/jats:italic>B\u20102\u2010negative. All three c\u2010<jats:italic>erb<\/jats:italic>B\u20102\u2010positive cases were also p53\u2010positive. The results indicate that p53 mutations and c\u2010<jats:italic>erb<\/jats:italic>B\u20102 gene alterations play a role in the neoplastic transformation of gall bladder epithelial cells. Co\u2010expression of p53 and c\u2010<jats:italic>erb<\/jats:italic>B\u20102 suggests that alterations of these genes might act in concert in the neoplastic transformation. The occurrence of p53 expression in gall bladder dysplasias suggests that p53 mutations could be an early event in the evolution of some gall bladder carcinomas, as has been suggested for some other types of tumours, such as lung squamous cell carcinomas.<\/jats:p>","DOI":"10.1002\/path.1711700111","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:18:34Z","timestamp":1119442714000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["p53 and c\u2010<i>erb<\/i>B\u20102 protein expression in adenocarcinomas and epithelial dysplasias of the gall bladder"],"prefix":"10.1002","volume":"170","author":[{"given":"Dia","family":"Kamel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paavo","family":"P\u00e4\u00e4kk\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ky\u00f6sti","family":"Nuorva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"V\u00e4h\u00e4kangas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ylermi","family":"Soini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"volume-title":"Tumors of the gallbladder and extrahepatic bile ducts. 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