{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:42:52Z","timestamp":1772898172995,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4397,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extravasation of leucocytes in tissues is mediated by leucocyte\u2014endothelial cell interactions in which adhesion molecules play an important role. Until now, two pathways have been unravelled, i.e., the LFA\u20101\/ICAM\u20101 and the VLA\u20104\/VCAM\u20101 pathways. ELAM\u20101 has been shown to be involved in granulocyte accumulation and recently also in lymphocyte migration. The role of HECA\u2010452 is under investigation. In this study we have investigated the expression of the above\u2010mentioned adhesion molecules in lung tissue of patients with pulmonary sarcoidosis and usual interstitial pneumonitis (UIP), and in mediastinal lymph nodes of patients with sarcoidosis. ICAM\u20101 (CD54) was broadly distributed on the endothelium of all the vessels found in sarcoidosis and UIP. VCAM\u20101 was present on the endothelium of the venules, capillaries, and arterioles in both sarcoidosis and UIP. ELAM\u20101 reacted with endothelial cells lining venules and capillaries in chronic progressive sarcoidosis and in the active phase of UIP but not in the stationary phases of both diseases. HECA\u2010452 activity could be detected only on high endothelial venules within sarcoid lymph nodes. In lung tissues, macrophages bearing the ICAM\u20101 antigen were present in sarcoid tissue but not in the interstitium and alveolar space of UIP. LFA\u20101 (CD11a\/CD18) and VLA\u20104 (CD49d\/CD29) were present on all leucocytes found but seemed to be more highly expressed on lymphocytes in sarcoidosis. These findings suggest that the LFA\u20101\/ICAM\u20101 and VLA\u20104\/VCAM\u20101 pathways are involved in leucocyte migration in both types of lung disease, while in the active phases of sarcoidosis and UIP, ELAM\u20101 is also involved.<\/jats:p>","DOI":"10.1002\/path.1711700210","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:20:14Z","timestamp":1119442814000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Identical expression of ELAM\u20101, VCAM\u20101, and ICAM\u20101 in sarcoidosis and usual interstitial pneumonitis"],"prefix":"10.1002","volume":"170","author":[{"given":"A. C. H. M.","family":"Van Dinther\u2010janssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. C. M. Th.","family":"Van Maarsseveen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J. L. 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Manuscript in preparation."},{"key":"e_1_2_1_27_2","first-page":"1063","article-title":"A unique phenotype of skin\u2010associated lymphocytes in humans","volume":"136","author":"Picker LJ","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_1_28_2","first-page":"147","article-title":"High endothelial differentiation in human and inflammatory tissue defined by monoclonal antibody HECA\u2010452","volume":"130","author":"Duijvestijn AM","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.3.819"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830161106"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/333850a0"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711700210","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711700210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:51:24Z","timestamp":1761069084000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711700210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["10.1002\/path.1711700210"],"URL":"https:\/\/doi.org\/10.1002\/path.1711700210","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]},"assertion":[{"value":"1992-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1992-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}