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Cytogenetic analysis on the lymph node biopsy at the time of diagnosis of PTL revealed the co\u2010existence of two distinct, abnormal cell clones. The first clone was characterized by a reciprocal translocation t(5;7)(q13;q35) involving 7q35, namely the TCR\u2010\u03b2 gene, as expected in T\u2010cell lymphomas. The second cell clone carried trisomies for chromosomes 2, 5, 7, and 14. By immunophenotypic and molccular analysis as well as by <jats:italic>in situ<\/jats:italic> hybridization, it was possible to prove that the malignant T\u2010cells and the Reed\u2010Sternberg cells corresponded to different cell clones, one carrying the structural chromosome abnormalities and one carrying the numerical chromosome anomalies. These results indicate that the present case represented a true composite lymphoma.<\/jats:p>","DOI":"10.1002\/path.1711700305","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:20:28Z","timestamp":1119442828000},"page":"239-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["T\u2010cell lymphoma developing in Hodgkin's disease: Evidence for two clones"],"prefix":"10.1002","volume":"170","author":[{"given":"Iwona","family":"Wlodarska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Delabie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"De Wolf\u2010peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mecucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Stul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Verhoef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Jacques","family":"Cassiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman Van Den","family":"Berghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712082972303"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198210143071601"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900050203"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92007-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197903013000902"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6209.216"},{"key":"e_1_2_1_8_2","first-page":"233","article-title":"Second primary cancers following treatment of Hodgkin's disease","volume":"72","author":"Boivin JF","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<459::AID-CNCR2820530315>3.0.CO;2-V"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801215)46:12<2596::AID-CNCR2820461211>3.0.CO;2-T"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30558-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199209000-00007"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_14_2","volume-title":"I.S.C.N. 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