{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:40Z","timestamp":1761058300676,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4367,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies on the proliferative compartment of human tissue mast cells (MCs) and their tumours (mastocytosis) have not been performed. We have used the monoclonal antibody PC 10 to study MCs in reactive or hyperplastic states (chronic non\u2010specific lymphadenitis, <jats:italic>n<\/jats:italic> = 10; benign and malignant solid tumours, <jats:italic>n<\/jats:italic> = 5) and in the various subtypes of mastocytosis (urticaria pigmentosa, <jats:italic>n<\/jats:italic> = 22; solitary mastocytoma of the skin, <jats:italic>n<\/jats:italic> = 7; systemic mastocytosis; <jats:italic>n<\/jats:italic> = 8; malignant mastocytosis, <jats:italic>n<\/jats:italic> = 4). The identification of PC10\u2010positive MC nuclei was achieved by double staining. We found no PC10\u2010positive MCs in reactive or hyperplastic states, or in 14 of 22 cases of urticaria pigmentosa. PC 10\u2010positive MCs could be identified in all other mastocytoses but mostly in very low numbers. The mean percentages of PC10\u2010positive MCs amounted to 0.5 in eight positive cases of urticaria pigmentosa, 1.2 in mastocytoma, 0.7 in sytemic mastocytosis, and 4.0 in malignant mastocytosis. The difference between the latter form of mastocytosis and each of the other subtypes proved to be significant (<jats:italic>P<\/jats:italic>&lt;0.05). The very smali proliferative compartment in the cutaneous and sytemic variants of mastocytosis is in accord with their favourable prognosis Most of the patients with systemic mastocytosis in the present study are all alive and well up to 12 years after diagnosis. In contrast, most of the patients with malignant mastocytosis died within 1 year of diagnosis.<\/jats:p>","DOI":"10.1002\/path.1711700308","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:20:28Z","timestamp":1119442828000},"page":"265-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Proliferation of reactive and neoplastic human tissue mast cells. An immunohistochemical study using the antibody PC10 (anti\u2010PCNA)"],"prefix":"10.1002","volume":"170","author":[{"given":"Hans\u2010Peter","family":"Horny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"McCullagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Wehrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Rochf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Kaiserling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"733","article-title":"Analysis of proliferative grade using anti\u2010PCN\u2010cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis","volume":"134","author":"Garcia RL","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01486688"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0170728"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80252-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890201)63:3<532::AID-CNCR2820630322>3.0.CO;2-F"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.00441.x-i1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07870.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920715)70:2<459::AID-CNCR2820700214>3.0.CO;2-4"},{"key":"e_1_2_1_11_2","unstructured":"HornyH\u2010P KaiserlingE ParwareschMR LennertK.Lymph node findings in generalized mastocytosis.Histopathology(in press)."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.4.1549"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711620403"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01047461"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90416-A"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841869109088244"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.5.416"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01600508"},{"key":"e_1_2_1_19_2","first-page":"923","article-title":"The clinical spectrum of urticaria pigmentosa","volume":"40","author":"Klaus SN","year":"1965","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(85)80184-9"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198811000-00001"},{"key":"e_1_2_1_22_2","first-page":"656","article-title":"Maligne Mastzellretikulose","volume":"113","author":"Steinke B.","year":"1988","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/291159a0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.1.144.144"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235339"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711700308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711700308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:29:13Z","timestamp":1761056953000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711700308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1002\/path.1711700308"],"URL":"https:\/\/doi.org\/10.1002\/path.1711700308","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1993,7]]},"assertion":[{"value":"1992-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1993-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}