{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:08:43Z","timestamp":1791893323116,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4336,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010nine cases of Langerhans cell histiocytosis (LCH), non\u2010Langerhans cell histiocytoses (N\u2010LCH), noninfectious granulomas, and fibroblast\u2010related lesions were examined with a panel of monoclonal and polyclonal antibodies on freshly frozen tissue sections to characterize the macrophage phenotype of N\u2010LCH syndromes. MS\u20101 high molecular weight extracellular protein, specific for sinusoidal endothelial cells and dendritic perivascular macrophages in normal human organs, was expressed by N\u2010LCH cells but was not found in LCH cells, epithelioid cells in sarcoidosis, or palisading histiocytes in granuloma annulare. The subcellular location of MS\u20101 protein, i.e., cytoplasmic vs. peripheral\/extracellular, allowed discrimination of small and large (foamy or multinucleated) N\u2010LCH cells. MS\u20101\u2010positive cells, which were found intermingled in cellular dermatofibromas but not in fibrous dermatofibromas, differed from MS\u20101\u2010positive N\u2010LCH cells by their dendritic morphology, and thus rather resembled their normal dermal counterparts. A preserved functional relationship of these two MS\u20101\u2010positive cell types was indicated by the fact that N\u2010LCH and cellular dermatofibromas were the only lesions found to be highly vascularized. As expected, CD1a showed high specificity for LCH, while CD34 was predominantly expressed by fibroblast\u2010related lesions; in cellular dermatofibromas, CD34 and MS\u20101 expression partially overlapped. The other antigens tested showed non\u2010specific or overlapping patterns of expression. In conclusion, assessment of MS\u20101 protein expression (in addition to assessment of CD1a and CD34) promises to be of diagnostic value in the discrimination of N\u2010LCH from related skin disorders, and it may indicate a common differentiative pathway for most N\u2010LCH disease entities.<\/jats:p>","DOI":"10.1002\/path.1711700404","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:22:34Z","timestamp":1119442954000},"page":"421-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Immunohistochemical comparison of cutaneous histiocytoses and related skin disorders: Diagnostic and histogenetic relevance of MS\u20101 high molecular weight protein expression"],"prefix":"10.1002","volume":"170","author":[{"given":"Sergij","family":"Goerdt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kolde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Bonsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Czarnetzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Andreesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Luger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Sorg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70181-8"},{"key":"e_1_2_1_3_2","first-page":"208","article-title":"Histiocytosis syndromes in children","volume":"1","author":"Favara BE","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199202000-00002"},{"key":"e_1_2_1_5_2","first-page":"282","article-title":"Monoclonal antibodies distinguish macrophages and epithelioid cells in sarcoidosis and leprosy","volume":"68","author":"Munro CS","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70310-E"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680190063007"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.6.1425"},{"key":"e_1_2_1_9_2","first-page":"732","article-title":"MS\u20101 sinusoidal endothelial antigen is expressed by factor XIIIa+, HLA\u2010DR+ dermal perivascular dendritic cells","volume":"65","author":"Walsh LJ","year":"1991","journal-title":"Lab Invest"},{"key":"e_1_2_1_10_2","first-page":"295","article-title":"A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the downregulation phase of the inflammatory process","volume":"55","author":"Zwadlo G","year":"1987","journal-title":"Exp Cell Biol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V67.5.1257.1257"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.137.2.512"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/330080a0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.134.3.1487"},{"key":"e_1_2_1_15_2","first-page":"185","article-title":"Characterization and differential expression of an endothelial cell\u2010specific surface antigen in continuous and sinusoidal endothelia, in skin vascular lesions and in vitro","volume":"57","author":"Goerdt S","year":"1989","journal-title":"Exp Cell Biol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1981.01650100069034"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb08406.x"},{"key":"e_1_2_1_18_2","first-page":"1409","article-title":"Inducible expression of MS\u20101 high molecular weight protein by endothelial cells of continuous origin and by dendritic cells\/macrophages in vivo and in vitro","volume":"142","author":"Goerdt S","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80116-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851101)56:9<2280::AID-CNCR2820560923>3.0.CO;2-L"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.2.598"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4554"},{"key":"e_1_2_1_23_2","first-page":"652","article-title":"Eruptive Histiozytome und Xanthoma disseminatum als Manifestationsformen derselben Erkrankung?","volume":"39","author":"Braun\u2010Falco O","year":"1988","journal-title":"Hautarzt"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.04510010091009"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb08036.x"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711700404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711700404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:59:36Z","timestamp":1761058776000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711700404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1002\/path.1711700404"],"URL":"https:\/\/doi.org\/10.1002\/path.1711700404","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,8]]},"assertion":[{"value":"1993-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1993-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}