{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:34:56Z","timestamp":1763764496998,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4305,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic intestinal ulceration in Crohn's disease is associated with the development of an epidermal growth factor\u2010secreting cell lineage, or \u2018ulcer\u2010associated cell lineage\u2019 (UACL).\n                    <jats:sup>1<\/jats:sup>\n                    Expression of oligosaccharides by UACL was studied using a panel of 25 biotinylated lectins with an avidin peroxidase revealing system and compared with that of adult and fetal Brunner's glands, gastric antral mucosa, and \u2018gastric metaplasia\u2019 within the duodenum, in order to clarify further the interrelationships of these lineages. UACL was obtained from ileal resections performed for Crohn's disease.\n                  <\/jats:p>\n                  <jats:p>Lectin binding of the glandular component of UACL closely resembled that of antral mucosal glands and also that of fetal and adult Brunner's glands. Lectin binding of the ductal component of immature UACL, in which a surface component had not developed, resembled that of the gland. The surface and ductal components of mature UACL showed a distinct lectin\u2010binding profile, which was very different from that of the gland, but closely resembled that of antral foveolar epithelium and \u2018gastric metaplasia\u2019 within the duodenum.<\/jats:p>\n                  <jats:p>It is concluded that there is differentiation of UACL from the glandular to surface components and that oligosaccharide expression of the lineage reflects that of normal Brunner's gland and gastric antral mucosa.<\/jats:p>","DOI":"10.1002\/path.1711710105","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:23:26Z","timestamp":1119443006000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Ulcer\u2010associated cell lineage (\u2018pyloric metaplasia\u2019) in crohn's disease: A lectin histochemical study"],"prefix":"10.1002","volume":"171","author":[{"given":"Ian S. D.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Stoddart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/343082a0"},{"key":"e_1_2_1_3_2","first-page":"205","article-title":"Aberrant pyloric glands in regional ileitis","volume":"51","author":"Liber AF","year":"1951","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700870207"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(55)80091-1"},{"key":"e_1_2_1_6_2","first-page":"173A","article-title":"Epidermal growth factor immunoreactive cells in Barrett's columnar oesophagus\u2014a clue to the mechanism of pathogenesis (Abstract)","volume":"163","author":"Gray MR","year":"1991","journal-title":"J Pathol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711620402"},{"key":"e_1_2_1_8_2","first-page":"65","volume-title":"Gastrointestinal and Oesophageal Pathology","author":"Filipe MI","year":"1989"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/40.1.1370305"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01885784"},{"volume-title":"Theory and Practice of Histological Techniques","year":"1982","author":"Bancroft JD","key":"e_1_2_1_11_2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01046163"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002487"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.93.1.163"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01048371"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(84)90352-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01047896"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(84)90417-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75678-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80887-6"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2310115"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(78)50043-8"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(88)80113-7"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1139\/v85-440"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(87)90074-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75677-4"},{"key":"e_1_2_1_27_2","first-page":"169A","article-title":"The morphogenesis of growth factor\u2010secreting tubules in the ulcerated gastrointestinal tract: the develop\u2010ment of a proliferative zone","volume":"163","author":"Ahnen D","year":"1991","journal-title":"J Pathol"},{"key":"e_1_2_1_28_2","first-page":"53","article-title":"The migration pathway of epithelial cells on human duodenal villi: the origin and fate of \u2018gastric metaplastic\u2019 cells in duodenal mucosa","volume":"1","author":"Liu KC","year":"1992","journal-title":"Epithelial Cell Biol"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.5.408"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711690313"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711710105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711710105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:15:38Z","timestamp":1761066938000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711710105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/path.1711710105"],"URL":"https:\/\/doi.org\/10.1002\/path.1711710105","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1993,9]]},"assertion":[{"value":"1992-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1993-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}