{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:07:39Z","timestamp":1791900459066,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4183,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Within the group of primary cutaneous T\u2010cell lymphomas (CTCLs), mycosis fungoides (MF), S\u00e9zary's syndrome (SS), and CD30\u2010positive lymphomas have been delineated as clinicopathological entities. Primary CTCLs that do not belong to one of these entities represent a heterogeneous and ill\u2010defined group of neoplasms. This paper describes the clinical and histological features of 35 of such cases. The object of t his study was to define prognostic parameters for this group of primary CTCLs. Using a slightly modified version of the updated Kiel classification, a subdivision was made into CTCL, pleomorphic, small cell type (<jats:italic>n<\/jats:italic> = 3); plemorphic, medium\u2010sized cell type (<jats:italic>n<\/jats:italic> = 6); pleomorphic, large cell type (<jats:italic>n<\/jats:italic> = 18); and immunoblastic lymphomas (<jats:italic>n<\/jats:italic> = 8). Altogether, these lymphomas had a poor prognosis with estimated 2\u2010 and 4\u2010year survival rates of 53 and 22 per cent, respectively. Patients with pleomorphic, small and medium\u2010sized cell lymphomas (<jats:italic>n<\/jats:italic> = 9) proved to have a significantly better survival that those with pleomkorphic, large cell lymphomas (<jats:italic>P<\/jats:italic> = 0\u00b7032) and immunoblastic lymphomas (<jats:italic>P<\/jats:italic> = 0\u00b7008). Primary cutaneous immunoblastic lymphomas had the worst prognosis with an estimated 2\u2010year survival rate of 14 per cent. Other parameters including age (<jats:italic>P<\/jats:italic> = 0\u00b7345), sex (<jats:italic>P<\/jats:italic> = 0\u00b7345), sex (<jats:italic>P<\/jats:italic> = 0\u00b7662), extent of skin lesions at presentation (<jats:italic>P<\/jats:italic> = 0\u00b70854), and mode of initial treatment (<jats:italic>P<\/jats:italic> = 0\u00b7609) had no significant effect on the survival time. The results of this study suggest that primary CTCLs other than classical MF, SS, and CD30\u2010positive lymphomas have a poor prognosis in most cases, and that the current classification may be a useful means of predicting the clinical behaviour in these lymphomas.<\/jats:p>","DOI":"10.1002\/path.1711720110","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:26:07Z","timestamp":1119443167000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Primary cutaneous T\u2010cell lymphoma: Clinicopathological features and prognostic parameters of 35 cases other than mycosis fungoides and cd30\u2010positive large cell lymphoma"],"prefix":"10.1002","volume":"172","author":[{"given":"Rob C.","family":"Beljaards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J. L. M.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan C. J.","family":"Van Der Putte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Hollema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Louise","family":"Geerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Dick","family":"Bezemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rein","family":"Willemze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"548","article-title":"cell lymphomas. Perspective","volume":"83","author":"Edelson R. L.","year":"1975","journal-title":"Ann Intern Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80385-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197609)38:3<1282::AID-CNCR2820380331>3.0.CO;2-N"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810115)47:2<300::AID-CNCR2820470216>3.0.CO;2-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851115)56:10<2458::AID-CNCR2820561022>3.0.CO;2-S"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V62.2.464.464"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.5.553"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930315)71:6<2097::AID-CNCR2820710626>3.0.CO;2-7"},{"key":"e_1_2_1_10_2","first-page":"3590","article-title":"Primary and secondary cutaneous Ki\u20101 + (CD30+) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical characteistics","volume":"135","author":"Kaudewitz P","year":"1989","journal-title":"Am J Pathol"},{"key":"e_1_2_1_11_2","first-page":"1169","article-title":"Prognostic significance of CD30 (Ki\u20101\/Ber\u2010H2) expression of primary cutaneous large\u2010cell lymphomas of T\u2010cell origin","volume":"135","author":"Beljaards RC","year":"1989","journal-title":"Am. J Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.9.995"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90367-4"},{"key":"e_1_2_1_14_2","first-page":"67","volume-title":"Using and Understanding Medical Statistics","author":"Mathews DE","year":"1998"},{"key":"e_1_2_1_15_2","first-page":"27","article-title":"Mycosis fungoides and its relation to S\u00e9zary's syndrome, lymphomatoid papulosis, and primary Hodgkin's diseae","volume":"55","author":"Brehmer\u2010Andersson E","year":"1976","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_1_16_2","first-page":"359","article-title":"Primary and secondary Ki\u20101 + (CD30 +) anaplastic large cell lymphomas","volume":"135","author":"Kaudewitz P","year":"1989","journal-title":"Am. J Pathol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000248433"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.44.2.119"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70043-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb15116.x"},{"key":"e_1_2_1_21_2","first-page":"204","volume-title":"Histopathologie der Non\u2010Hodgkin Lymphome nach der aktualiserten Kiel\u2010Klassifikation","author":"Lennert K","year":"1990"},{"key":"e_1_2_1_22_2","first-page":"218","volume-title":"Major Problems in Pathology","author":"Jaffe ES","year":"1985"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.5.1674.1674"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198811000-00007"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70269-N"},{"key":"e_1_2_1_26_2","first-page":"946","article-title":"Etude sur le mycosis fungoides","volume":"2","author":"Vidal E","year":"1985","journal-title":"Fr Med"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198911020-00002"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199110000-00013"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711720110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711720110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711720110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711720110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:30:01Z","timestamp":1761057001000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711720110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/path.1711720110"],"URL":"https:\/\/doi.org\/10.1002\/path.1711720110","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]},"assertion":[{"value":"1993-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1993-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}