{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:14:37Z","timestamp":1770822877460,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4124,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to assess its discriminating and prognostic value, we studied immunoreactivity for proliferating nuclear cell antigen (PCNA) in human malignant mesothelioma (31 cases) and in human non\u2010neoplastic mesothelium (33 cases with reactive mesothelium and 20 cases of normal mesothellum) using the murine monoclonal antibody PC 10. We also compared it with mitosis counts expressed as the mitotic volume index (MV index). There were differences between malignant mesothelioma, reactive mesothelium, and normal mesothelium for percentage of PCNA immunoreactive cells (mean \u00b1 SD; 27 \u00b1 9, 9\u00b75 \u00b1 5\u00b71, and 3\u00b76 \u00b1 1\u00b76, respectively) and for their MV index (20\u00b73 \u00b1 4\u00b75, 9\u00b74 \u00b1 2\u00b71, and 3\u00b76 \u00b1 0\u00b76, respectively). The median actuarial survival was 10\u00b71 months for patients with less than 25 per cent PCNA immunoreactive cells, 9\u00b74 months for patients with less than 20 mitoses per mm<jats:sup>2<\/jats:sup> of tumoural tissue, 5\u00b79 months for patients with more than 25 per cent PCNA immunoreactive cells, and 5\u00b73 months for patients with more than 20 mitoses per mm<jats:sup>2<\/jats:sup> of tumoural tissue. Our results suggest that PCNA immunoreactivity is useful in discriminating between neoplastic and non\u2010neoplastic mesothelium and that it may have prognostic value in malignant mesothelioma.<\/jats:p>","DOI":"10.1002\/path.1711720304","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:27:57Z","timestamp":1119443277000},"page":"247-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Proliferation in malignant mesothelioma as determined by mitosis counts and immunoreactivity for proliferating cell nuclear antigen 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