{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:31:55Z","timestamp":1761762715193,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4093,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Expression of syndecan\u20101, a cell surface proteoglycan that binds growth factors and extracellular matrix components, was studied in normal and pathological human uterine cervix using immunohistochemical methods. Normal cervical squamous epithelium showed positive staining for syndecan\u20101 in all cell layers, except the basal cell layer, whereas endocervical columnar epithelium stained weakly. In non\u2010neoplastic reactive lesions, metaplastic squamous cells were positive for syndecan\u20101, whereas columnar cells showed weak or negative staining. In cervical condylomas, cells showing koilocytotic atypia were positive for syndecan\u20101. The progression of cervical intraepithelial neoplasia (CIN) grade I to grade III was associated with reduced syndecan\u20101 expression and localization of syndecan\u20101 to more superficial cell layers. In squamous cell carcinomas (SCCs), syndecan\u20101 expression correlated with histological differentiation, being absent from most poorly differentiated tumours. The results suggest that loss of syndecan\u20101 from atypical cells is an early event during cervical carcinogenesis and show a close association of syndecan\u20101 expression with preserved epithelial morphology and differentiation.<\/jats:p>","DOI":"10.1002\/path.1711720410","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:28:41Z","timestamp":1119443321000},"page":"349-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Immunohistochemical localization of syndecan\u20101 in normal and pathological human uterine cervix"],"prefix":"10.1002","volume":"172","author":[{"given":"Pirjo","family":"Inki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frej","family":"Stenb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seija","family":"Grenman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"Jalkanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)80001-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.60.070191.002303"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.08.110192.002053"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60305-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711690204"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90512-W"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8456318"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)80471-2"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.4052\/tigg.5.107"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)38239-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)89510-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.18.6985"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42715-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.113.1.339"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90401-0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/35.10.2957423"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42911-0"},{"key":"e_1_2_1_19_2","first-page":"1333","article-title":"Immunohistochemical localization of syndecan in mouse skin tumors induced by UV irradiation; 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