{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:20:40Z","timestamp":1784604040914,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":4002,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The distribution of the two trefoil peptides pS2 and human spasmolytic polypeptide (hSP) and their mRNAs was investigated in 90 selected oesophageal biopsies, 23 of which contained epithelium with wholly gastric cardiac\u2010type morphology, 52 specialized (intestinal)\u2010type metaplasia, and 15 non\u2010metaplastic oesophageal epithelium. No fundic\u2010type epithelium was represented. The cardiac\u2010type epithelium resembled true gastric antral epithelium, with hSP and pS2 mRNA localization to the superficial\/foveolar compartment and hSP mRNA alone in deeper glands. The pattern of peptide distribution was broadly in line with the mRNA, but hSP peptide was generally not demonstrable in the surface epithelium. pS2 immunostaining was diffusely cytoplasmic, whereas in specialized\u2010type mucosa it was aggregated and cytoplasmic hSP mRNA was demonstrable in surface epithelium of incomplete\u2010 but not complete\u2010type intestinal (specialized) metaplasia. Deep glands with morphological features of pyloric glands\/ulcer\u2010associated cell lineage (UACL) typically contained only hSP peptide and its mRNA. In three biopsies containing specialized epithelium, small foci morphologically identical to true small intestinal surface epithelium were seen in which only pS2 mRNA and peptide were found and then only in rare goblet cells. Neither squamous epithelium nor oesophageal glands contained demonstrable pS2\/hSP mRNA or peptide. The function of these proteins in the metaplastic mucosa of Barrett's oesophagus is unknown but they may reflect an epithelium responding to repeated insult. Their localization facilitates definition of the disparate epithelium types seen in this portion of the gut, with both native gastric and intestinal epithelia, and may help to pinpoint high\u2010risk epithelium in Barrett's oesophagus, a potentially preneoplastic condition.<\/jats:p>","DOI":"10.1002\/path.1711730303","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T12:30:19Z","timestamp":1119443419000},"page":"213-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in Barrett's metaplasia and the native oesophageal epithelium: Delineation of epithelial phenotype"],"prefix":"10.1002","volume":"173","author":[{"given":"Andrew M.","family":"Hanby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz A. Z.","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Poulsom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","article-title":"Trefoil peptide: a newly recognized family of epithelial mucin\u2010associated molecules","volume":"265","author":"Poulsom R","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_1_2_3","first-page":"G205","volume":"28","journal-title":"Gastrointest Liver Physiol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(82)90126-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(89)90288-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(85)90226-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68553-9"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200390"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200390"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(82)90128-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81357-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03443.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend-3-3-552"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.6.2861"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711620402"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/343082a0"},{"key":"e_1_2_1_16_2","first-page":"1","article-title":"Oesophageal cancer; 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