{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:59:25Z","timestamp":1773755965463,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3849,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The recombination events of the \u03b3 and \u03b2 T\u2010cell receptor (TCR) loci were analysed in a series of 39 peripheral T\u2010cell lymphomas (PTCLs) in association with the expression of TCR chains. In TCR \u03b1\u03b2 PTCLs, 22\/23 cases showed a \u03b3\u2010gene rearrangement while only 18\/23 showed a concomitant \u03b2\u2010gene rearrangement. The germline configuration of the \u03b2 locus was found in angioimmunoblastic lymphadenopathy and lymphoepithelioid lymphomas. Three \u03b3\u03b4 PTCLs rearranged both \u03b3 and \u03b2 genes. TCR silent PTCLs showed three different patterns of \u03b3\u2010 and \u03b2\u2010gene rearrangements. Three cases were in germline configuration for both loci; five cases had a rearranged \u03b3 and a germline \u03b2 locus; and five cases had the two loci rearranged. Regarding the variable genes in the \u03b3\u2010rearranged alleles, members of the V\u03b3I subgroup were the most frequently presented (39\/50), followed by V\u03b3II, V\u03b3III, and V\u03b3IV (9\/50, 1\/50, and 1\/50, respectively). Joining segment usage was as follows: J1 or J2 (32\/50), JP1 or JP2 (17\/50), and JP (1\/50). Taken together, these data demonstrate that the \u03b3 locus is more frequently rearranged whatever the TCR expression. The \u03b3\u2010locus analysis provides a better diagnostic yield than the \u03b2 locus in the study of PTCL clonality.<\/jats:p>","DOI":"10.1002\/path.1711740402","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:08:48Z","timestamp":1119445728000},"page":"233-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Recombination pattern of the TCR \u03b3 locus in human peripheral T\u2010cell lymphomas"],"prefix":"10.1002","volume":"174","author":[{"given":"Joannis","family":"Theodorou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Rapha\u00ebl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Bigorgne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Fourcade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Lahet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Cochet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Paule","family":"Lefranc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Gaulard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Farcet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.003225"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/314103a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2658058"},{"key":"e_1_2_1_5_2","first-page":"413","article-title":"Rearrangement 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