{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:42:06Z","timestamp":1770504126657,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3787,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>p53 expression has been examined in 89 squamous cell carcinomas of the larynx (34 glottic, 28 supraglottic, 18 transglottic, 8 pyriform sinus, and 1 subglottic) obtained from 88 patients surgically treated in our centre. In addition, 59 laryngeal samples including normal respiratory epithelium and non\u2010invasive squamous cell lesions were also tested. Frozen sections were immunostained with PAb 1801 and the results were correlated with pathological features, DNA ploidy and S\u2010phase of the tumours, disease\u2010free interval, and survival of the patients. p53 immunoreactivity was observed in 57 (64 per cent) carcinomas. None of the eight samples of normal respiratory epithelium was positive. p53\u2010positive cells were seen in 8 of 23 (35 per cent) squamous cell metaplasias, 6 of 19 (32 per cent) low\u2010grade dysplasias and 5 of 10 (50 per cent) high\u2010grade dysplasias. No correlation was found between p53 expression in carcinomas and their clinical and pathological characteristics, DNA ploidy, or proliferative activity. Neither disease\u2010free nor overall survival showed differences between p53\u2010positive and p53\u2010negative cases. These findings indicate that p53 may play a role in an early stage of malignant transformation of a subset of squamous cell carcinomas of the larynx, but seems not to be associated with further progression of the tumours.<\/jats:p>","DOI":"10.1002\/path.1711750205","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:12:34Z","timestamp":1119445954000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["p53 expression in normal, dysplastic, and neoplastic laryngeal epithelium. Absence of a correlation with prognostic factors"],"prefix":"10.1002","volume":"175","author":[{"given":"Alfons","family":"Nadal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00edas","family":"Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carme","family":"Mallofr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Palac\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Arias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Traserra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cardesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910410403"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860815)58:4<928::AID-CNCR2820580421>3.0.CO;2-J"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920701)70:1<56::AID-CNCR2820700110>3.0.CO;2-Q"},{"key":"e_1_2_1_5_2","first-page":"39","volume-title":"The Pathology of Incipient Neoplasias","author":"Crissman JD","year":"1986"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90593-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1905840"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90801-B"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.19.7555"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.352"},{"key":"e_1_2_1_11_2","first-page":"4832","article-title":"Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer","volume":"52","author":"Brachman DG","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","first-page":"431","article-title":"p53 expression in end stage squamous cell carcinoma of the head and neck prior to chemotherapy treatment: expression correlates with a very poor clinical outcome","volume":"3","author":"Field JK","year":"1993","journal-title":"Int J Oncol"},{"key":"e_1_2_1_13_2","first-page":"1159","article-title":"High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx","volume":"7","author":"Maestro R","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520204"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530615"},{"key":"e_1_2_1_16_2","first-page":"33","volume-title":"Iarynx. Manual for Staging of Cancer","author":"American Joint Committee on Cancer","year":"1992"},{"key":"e_1_2_1_17_2","first-page":"4436","article-title":"Loss of heterozygosity of p53 gene and p53 protein expression in human colorectal carcinomas","volume":"51","author":"Campo E","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990100302"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990140503"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880220064009"},{"key":"e_1_2_1_21_2","first-page":"4817","article-title":"p53 protein accumulates frequently in early bronchial neoplasia","volume":"53","author":"Bennett WP","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_2","first-page":"1783","article-title":"Accumulation of p53 protein in human esophageal precancerous lesions: a possible early biomarker for carcinogenesis","volume":"53","author":"Wang L\u2010D","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711700310"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460515"},{"key":"e_1_2_1_25_2","first-page":"5520","article-title":"Aberration of tumor suppressor p53 and retinoblastoma genes in human hepato\u2010cellular carcinomas","volume":"51","author":"Murakami","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199304000-00008"},{"key":"e_1_2_1_27_2","first-page":"1393","article-title":"Frequent association of p53 gene mutation in invasive bladder cancer","volume":"52","author":"Fujimoto K","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90866-2"},{"key":"e_1_2_1_29_2","first-page":"4189","article-title":"Expression of mutated p53 occurs in tumor\u2010distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors","volume":"53","author":"Nees M","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_30_2","first-page":"1676","article-title":"Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract","volume":"53","author":"Chung KY","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_31_2","first-page":"1779","article-title":"Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancers","volume":"6","author":"Bennett WP","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_32_2","first-page":"6092","article-title":"p53 mutation and protein accumulation during multistage human esophageal carcinogenesis","volume":"52","author":"Bennett WP","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711660402"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90421-8"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.14.1109"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.11.845"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.74"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.348"},{"key":"e_1_2_1_39_2","first-page":"2979","article-title":"Overexpression and mutation of p53 in epithelial ovarian cancer","volume":"51","author":"Marks JR","year":"1991","journal-title":"Cancer Res"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711750205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711750205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:50:38Z","timestamp":1761040238000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711750205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1002\/path.1711750205"],"URL":"https:\/\/doi.org\/10.1002\/path.1711750205","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]},"assertion":[{"value":"1994-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1994-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}