{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:06:33Z","timestamp":1771067193213,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3787,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Islet amyloid polypeptide (IAPP) is the main proteinaceous component of pancreatic islet amyloid, which is a characteristic feature of type 2 diabetes. The factors responsible for amyloid deposition are unclear. Patients with end\u2010stage renal failure (ESRF) on dialysis treatment have increased insulin resistance which is associated with hypersecretion of beta\u2010cell products. Furthermore, elevated concentrations of circulating IAPP are found in these patients due to reduced renal clearance of IAPP. To determine the prevalence of islet amyloid in this group of patients, pancreas was examined from 23 non\u2010diabetic [aged 62 (29\u201079) years, median and range] and four type 2 diabetic [aged 67 (56\u201072) years] patients with ESRF on dialysis treatment. Pancreatic specimens from 30 non\u2010diabetic control subjects [aged 67.5 (56\u201086) years] and 14 type 2 diabetic subjects without renal disease [aged 69 (48\u201086) years] were used as control groups. Islet amyloid was present in all type 2 diabetic patients with ESRF and in 12 out of 14 type 2 diabetic control subjects (86 per cent). Amyloid deposits were found in 8 out of 23 non\u2010diabetic patients with ESRF (35 per cent), which was a higher prevalence than that found in non\u2010diabetic control subjects (3 per cent) (<jats:italic>P<\/jats:italic>&lt;0.01). This may be related to undiagnosed (pre)diabetes. Elevated secretion rates of IAPP due to insulin resistance and high circulation IAPP concentrations as a result of severely reduced renal clearance of IAPP will cause high pericellular concentrations of IAPP. This condition is likely to enhance amyloid fibril formation in pancreatic islets similar to that observed in type 2 diabetes.<\/jats:p>","DOI":"10.1002\/path.1711750214","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:12:34Z","timestamp":1119445954000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["High prevalence of pancreatic islet amyloid in patients with end\u2010stage renal failure on dialysis treatment"],"prefix":"10.1002","volume":"175","author":[{"given":"E. J. P.","family":"de Koning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W. R.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.4.5.367"},{"key":"e_1_2_1_3_2","first-page":"151","article-title":"Islet amyloid, increased A\u2010cells, reduced B\u2010cells, and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes","volume":"9","author":"Clark A","year":"1988","journal-title":"Diabetes Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402271"},{"key":"e_1_2_1_5_2","first-page":"416","article-title":"Spontaneous diabetes mellitus\u2010islet amyloid complex in adult cats","volume":"125","author":"Johnson KH","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_1_6_2","first-page":"291","article-title":"The pancreatic islet cell in insular amyloidosis in human diabetic and non\u2010diabetic islets","volume":"81","author":"Westermark P","year":"1973","journal-title":"Acta Pathol Microbiol Scand Sect A"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00251826"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80197-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(80)80165-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00285291"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00221649"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81527-3"},{"key":"e_1_2_1_13_2","first-page":"305","article-title":"Evidence of con\u2010secretion of islet amyloid polypeptide and insulin by \u03b2\u2010cells","volume":"40","author":"Kahn SE","year":"1990","journal-title":"Diabetes"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8227(90)90043-S"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00549079"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90825-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610080204"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.38.11.1333"},{"key":"e_1_2_1_19_2","first-page":"131","article-title":"Increased levels of plasma amylin in advanced renal failure","volume":"37","author":"Watschinger B","year":"1992","journal-title":"Clin Nephrol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109144"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110067"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90546-N"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000407589"},{"key":"e_1_2_1_24_2","first-page":"1029","article-title":"Amyloidiesis of possible new type in patients receiving long\u2010term hemodialysis","volume":"109","author":"Morita T","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91948-5"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112257"},{"key":"e_1_2_1_27_2","first-page":"205","article-title":"Duthie Rb and systemic distribution of dialysis amyloid","volume":"78","author":"Athanasou NA","year":"1991","journal-title":"Q J Med"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5036"},{"key":"e_1_2_1_29_2","first-page":"694A","article-title":"Increased amylin levels in patients on chronic haemosiay","volume":"8","author":"Ludvik B","year":"1990","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-45-3-441"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399099"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000184328"},{"key":"e_1_2_1_33_2","unstructured":"van KoningEJP MorrisER Hofhuis FMA et al.I extracellular amyloid fibrils are formed in cultured pancre of transgenic mice expressing human islet amyloid polyProc Natl Acad Sci USA(in press)."}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711750214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711750214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T09:50:55Z","timestamp":1761040255000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711750214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1002\/path.1711750214"],"URL":"https:\/\/doi.org\/10.1002\/path.1711750214","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]},"assertion":[{"value":"1994-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1994-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}