{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:27:31Z","timestamp":1790029651147,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3759,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have examined immunohistochemically the expression of adhesion molecules in the micro\u2010environment of portal tracts and their relationship to the expression of the pyruvate dehydrogenase E2 complex (PDC\u2010E2) and HLA\u2010DR in liver biopsy specimens.<\/jats:p><jats:p>Ten cases of primary biliary cirrhosis (PBC) and 19 controls were examined, including four cases of extrahepatic biliary obstruction, six of chronic viral hepatitis, and nine normal livers. In PBC, the damaged small bile ducts demonstrated an increased expression of PDC\u2010E2 and an aberrant expression of HLA\u2010DR; about half of these damaged bile ducts also expressed intercellular adhesion molecules (ICAM)\u20101 and a few expressed vascular adhesion molecule (VCAM)\u20101. In addition, lymphocyte function\u2010associated antigen (LFA)\u20101 and very late antigen (VLA)\u20104 were expressed on infiltrating lymphocytes around these bile ducts. In contrst, in control livers, these alterations in antigen expression on the bile ducts were either not observed or were only focal and weak, when present. These findings suggest that ICAM\u20101\/LFA\u20101 and also VCAM\u20101\/VLA\u20104 linkages between the damaged bile ducts and lymphocytes may facilitate antigen\u2010specific reactions such as the presentation of antigens, possibly PDC\u2010E2, to the periductal lymphocytes in PBC. ICAM\u20101, VCAM\u20101, and E\u2010selectin were strongly expressed on the endothelial cells of some vessels in the portal tracts in PBC, suggesting the facilitation of the recruitment of lymphocytes around the of some vessels in the portal tracts in PBC, suggesting the facilitation of the recruitment of lymphocytes around the bile ducts of PBC. VCAM\u20101, a member of the immunoglobulin superfamily, has not hitherto been reported on bile ducts.<\/jats:p>","DOI":"10.1002\/path.1711750310","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:12:36Z","timestamp":1119445956000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Immunohistochemical analysis of adhesion molecules in the micro\u2010environment of portal tracts in relation to aberrant expression of PDC\u2010E2 and HLA\u2010DR on the bile ducts in primary biliary cirrhosis"],"prefix":"10.1002","volume":"175","author":[{"given":"Mitsue","family":"Yasoshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuni","family":"Nakanuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Tsuneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"van de Water","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eric 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