{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:28:01Z","timestamp":1761092881519,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3575,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>BCL\u20106 is a novel proto\u2010oncogene that codes for a zinc\u2010finger protein sharing homologies with many transcription factors. It has recently been shown that BCL\u20106 is involved in chromosome band 3q27 aberrations in non\u2010Hodgkin's lymphomas (NHLs) and BCL\u20106 rearrangements have been detected in 34\u201345 per cent of diffuse large cell lymphomas with B immunophenotype. We have studied the BCL\u20106 gene configuration by Southern blot analysis in 60 cases of B\u2010cell NHL and in 17 cases of Hodgkin's disease (HD). BCL\u20106 was rearranged in 15\/46 (32\u00b76 per cent) diffuse B\u2010large cell lymphomas, mainly with centroblastic morphology, and in 2\/11 (18\u00b72 per cent) follicular (centroblastic\u2010centrocytic) lymphomas. Conversely, all cases of HD, including four cases of lymphocyte predominant, nodular type (nodular paragranuloma), had a germline configuration. These findings confirm that BCL\u20106 is rearranged in a significant percentage of diffuse B\u2010large cell lymphomas, suggesting that this proto\u2010oncogene might have a pathogenetic role in this subset of NHLs, but our preliminary analysis suggests that BCL\u20106 lesions are not involved in the pathogenesis of HD. However, further investigations using more sensitive techniques are required to confirm these findings.<\/jats:p>","DOI":"10.1002\/path.1711770105","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:18:23Z","timestamp":1119446303000},"page":"21-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of the BCL\u20106 gene configuration in diffuse B\u2010cell non\u2010Hodgkin's lymphomas and Hodgkin's disease"],"prefix":"10.1002","volume":"177","author":[{"given":"Edoardo","family":"Pescarmona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lo Coco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Pacchiarotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Rapanotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cimino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Di Paolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo D.","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90367-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7837"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3874430"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7439"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/315340a0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.2.493.493"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235596"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.7.1757.1757"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.9.2423.2423"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/5.suppl_1.S55"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711053171904"},{"key":"e_1_2_1_14_2","first-page":"343","article-title":"BCL\u20101 rearrangements in B\u2010cell lymphoma","volume":"2","author":"Ince C","year":"1988","journal-title":"Leukemia"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.5.684"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.2.259.bloodjournal782259"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/319336a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(91)90015-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)91175-0"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.5.2124"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90690-G"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.10.855"},{"key":"e_1_2_1_25_2","first-page":"211","article-title":"Hodgkin's disease, lymphocyte predominance, nodular. 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