{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:53:49Z","timestamp":1791042829988,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3575,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homozygote hypotransferrinaemic mice (hpx\/hpx) have cytopathological features similar to those of human congenital atransferrinaemia, genetic haemochromatosis, and neonatal haemochromatosis. These conditions all have in common high levels of cytotoxic non\u2010transferrin\u2010bound serum iron. This study describes the ultrastructural features of iron overload in liver, pancreas, heart, and small intestine of 2\u2010 and 12\u2010month\u2010old hypotransferrinaemic mice. Electron microscopic studies of unstained sections showed early parenchymal cell siderosis, with accumulation of numerous ferritin particles and clusters in the cytosol, as well as ferritin and haemosiderin in lysosomes (siderosomes). In the 12\u2010month\u2010old animals, iron was also found in Kupffer cells and macrophages in other tissues. In addition, there were conspicuous iron\u2010containing compounds in the bile canaliculi, and marked iron deposition in the pancreas and heart. Laser microprobe mass analysis (LAMMA) enabled localization and relative quantitation of iron deposition in subcellular compartments providing <jats:italic>in situ<\/jats:italic> documentation of iron accumulation in siderosomes and contributed in assessing total cytosolic iron in various cell types. Moreover, it demonstrated the importance and magnitude of the biliary route for iron excretion in these animals.<\/jats:p>","DOI":"10.1002\/path.1711770113","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:18:23Z","timestamp":1119446303000},"page":"83-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The hypotransferrinaemic mouse: Ultrastructural and laser microprobe analysis observations"],"prefix":"10.1002","volume":"177","author":[{"given":"Theodore C.","family":"Iancu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Shiloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishor B.","family":"Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Good","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"690","article-title":"Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia","volume":"110","author":"Bernstein SE","year":"1987","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb55498.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.482.482"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1113001"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V40.2.239.239"},{"key":"e_1_2_1_7_2","first-page":"75","article-title":"Neonatal hemochromatotis","volume":"23","author":"Knisely AS","year":"1987","journal-title":"Birth Defects"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0065-3101(24)00290-1","article-title":"Neonatal hemochromatosis","volume":"39","author":"Knisely AS","year":"1992","journal-title":"Adv Pediatr"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb04490.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711710313"},{"key":"e_1_2_1_11_2","first-page":"173","volume-title":"Inorganic Mass Spectrometry","author":"Verbueken AH","year":"1988"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310310"},{"key":"e_1_2_1_13_2","first-page":"363","article-title":"The iron\u2010loaded cell\u2014the cytopathology of iron storage","volume":"91","author":"Richter GW","year":"1978","journal-title":"Am J Pathol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1977.tb01026.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(83)90004-3"},{"key":"e_1_2_1_16_2","first-page":"26","article-title":"Studies of iron overload. 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