{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:16:34Z","timestamp":1761707794759,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3545,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A group of 166 patients with coeliac disease was followed for a period of up to 25 years. During this time, 17 patients developed intestinal tumours that were diagnosed as lymphoma, of which 15 cases were available for review. Eleven of the lymphomas were of T\u2010cell type (enteropathy\u2010associated T\u2010cell lymphoma, EATL) and two were of B\u2010cell type. Two cases were reclassified as undifferentiated carcinoma. The interval between the diagnosis of enteropathy and the onset of lymphoma varied from less than 2 months in four patients to more than 5 years in seven. Seven of the T\u2010cell and both B\u2010cell lymphomas were investigated for the presence of Epstein\u2013Barr virus (EBV) by <jats:italic>in situ<\/jats:italic> hybridization (ISH) using probes against Epstein\u2013Barr virus\u2010encoded RNAs (EBERs) and by immuno\u2010histochemistry with EBV\u2010specific monoclonal antibodies. All EATL cases were negative, suggesting that EBV is not an important factor in these cases. In one of the B\u2010cell cases, EBV was detectable by ISH and immunohistochemistry in most tumour cells in the mesenteric lymph nodes, but not in any of the tumour cells in the primary ileal tumour, indicating that in this case EBV infection was a late event in the neoplastic process. These results show that lymphoma may develop any time after the onset of coeliac disease and that in our cases of EATL, EBV was not an important factor. In some cases of EBV\u2010related neoplasia, virus infection may be a late event.<\/jats:p>","DOI":"10.1002\/path.1711770203","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:41:20Z","timestamp":1119447680000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Non\u2010Hodgkin's lymphoma, coeliac disease, and Epstein\u2013Barr virus: A study of 13 cases of enteropathy\u2010associated T\u2010 and B\u2010cell lymphoma"],"prefix":"10.1002","volume":"177","author":[{"given":"M.","family":"Ilyas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Niedobitek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Agathanggelou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Read","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. S.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1953.tb05563.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1953.tb05586.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.2.149"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(60)80115-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5725.725"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90737-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(60)80143-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6552.908"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.3.333"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90060-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.3.3.232"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92930-7"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.3.339"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.2.484.484"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199202000-00008"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.7.1789.1789"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67236-1"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.2.810.810"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb01236.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.2.619.619"},{"key":"e_1_2_1_22_2","first-page":"433","volume-title":"The Epstein\u2010Barr Virus and Associated Diseases","author":"Hummel H","year":"1993"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711700207"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.1.217.bloodjournal821217"},{"key":"e_1_2_1_25_2","first-page":"433","article-title":"Enteropathy\u2010associated T\u2010cell lymphoma in a renal transplant patient with evidence of Epstein\u2010Barr virus involvement","volume":"421","author":"Borisch B","year":"1992","journal-title":"Virchows Arch B"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711690206"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.472"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112123252406"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90333-8"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90369-N"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93059-I"},{"key":"e_1_2_1_32_2","first-page":"722","article-title":"Genotypic analysis of coeliac disease and enteropathy\u2010associated T\u2010cell lymphoma","volume":"189","author":"Jones DB","year":"1993","journal-title":"Pathol Res Pract"},{"key":"e_1_2_1_33_2","unstructured":"HowellWM ShuTong Leung JonesDB NakshabendiI WrightDH.HLA\u2010DRB DQA and DQB polymorphism in coeliac disease and enteropathy associated T\u2010cell lymphoma: common features and additional risk factors for malignancy. Submitted."},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","unstructured":"ChangK ChenYY WeissLM.Lack of evidence of Epstein\u2010Barr viruses in hairy cell leukemia and monocytoid B cell lymphoma.Hum Pathol1993;58\u201361.","DOI":"10.1016\/0046-8177(93)90063-M"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.10.2520.bloodjournal79102520"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910460509"},{"key":"e_1_2_1_37_2","first-page":"1461","article-title":"Abundant expression of EBER 1 small nuclear RNA in nasopharyngeal carcinoma\u2014a morphologically distinctive target for detection of Epstein\u2010Barr virus in formalin\u2010fixed paraffin\u2010embedded carcinoma specimens","volume":"138","author":"Wu TC","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.23.9006"},{"key":"e_1_2_1_39_2","first-page":"81","article-title":"Epstein\u2010Barr virus\u2010associated carcinomas","volume":"1","author":"Niedobitek G","year":"1994","journal-title":"EBV Rep"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90803-2"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1994.tb01289.x"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9524"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711770203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711770203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:07:50Z","timestamp":1761059270000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711770203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1002\/path.1711770203"],"URL":"https:\/\/doi.org\/10.1002\/path.1711770203","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1995,10]]},"assertion":[{"value":"1994-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}