{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:39:18Z","timestamp":1761093558169,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3514,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The \u03b2\u2010globin locus control region is known to be a powerful erythroid\u2010specific enhancer. In an attempt to produce immortalized erythroid percursor cells, transgenic mice have been generated with the simian virus (SV) 40 T antigen gene under the control of the locus control region. As previously reported, transgenic mice did not develop erythroleukaemia, but rather succumbed to insulinomas and poorly differentiated rhabdomyosarcomas. This paper describes additional mice containing this transgene that developed thymomas of the mixed epithelial\/lymphocytic type, in which only the epithelial component expressed the T antigen. Epithelial cell lines have been established from these tumours. This system may be useful in future studies on the pathogenesis of thymomas and the function of thymic epithelial cells.<\/jats:p>","DOI":"10.1002\/path.1711770314","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:41:35Z","timestamp":1119447695000},"page":"309-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid\u2010specific enhancer"],"prefix":"10.1002","volume":"177","author":[{"given":"Tal","family":"Teitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy C.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuet Wai","family":"Kan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S. Benedict","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.7.3979-3985.1992"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/315115a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5439"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/338352a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.7.2910"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.6.1007"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10444"},{"key":"e_1_2_1_9_2","unstructured":"TeitzT YenTSB ChangJC KanYW.SV40 T antigen directed by a powerful erythroid enhancer\u2010promoter produced sarcoma and pancreatic tumors but not erythroid specific tumors in transgenic mice.DNA Cell Biol(in press)."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.7033"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90282-8"},{"volume-title":"Tumors of the Thymus","year":"1975","author":"Rosai J","key":"e_1_2_1_12_2"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000150142"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90367-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.9.3178"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5096"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/342185a0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.12.5491"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001120102"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700950125"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1711770314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1711770314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:00:46Z","timestamp":1761048046000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1711770314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1002\/path.1711770314"],"URL":"https:\/\/doi.org\/10.1002\/path.1711770314","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[1995,11]]},"assertion":[{"value":"1994-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}