{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:43:13Z","timestamp":1774665793004,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T00:00:00Z","timestamp":1118793600000},"content-version":"vor","delay-in-days":3484,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent immunohistochemical study found increased numbers of eosinophils, but no mast cells, in the pulmonary parenchyma of infants who died of sudden infant death syndrome (SIDS). The present study tested the hypothesis that this pulmonary eosinophilia could be IgE\u2010mediated. Histomorphometry was used to compare the numbers of eosinophils, mast cells, and IgG\u2010, IgA\u2010, IgM\u2010 and IgE\u2010expressing lymphoid cells in the lungs of two groups of infants. Twenty\u2010eight subjects aged less than 1 year were selected from post\u2010mortem records of infant deaths between 1989 and 1992. Fourteen were cases of SIDS and these infants were matched for age and gender to 14 controls who died of other non\u2010pulmonary conditions. Immunohistochemical stains were used and positive cells were counted on six peribronchial and six subpleural fields. The numbers of eosinophils in both peribronchial and subpleural regions were significantly higher in SIDS compared with controls (<jats:italic>P<\/jats:italic>=0\u00b70071 and <jats:italic>P<\/jats:italic>=0\u00b7041, respectively). The numbers of IgA\u2010expressing lymphoid cells were also significantly increased in SIDS cases (<jats:italic>P<\/jats:italic>=0\u00b7042). There were no differences in IgG, IgM or IgE expression or in mast cell numbers. These results confirmed that pulmonary eosinophils are increased in SIDS, but not through an IgE\u2010mediated pathway.<\/jats:p>","DOI":"10.1002\/path.1711770413","type":"journal-article","created":{"date-parts":[[2005,6,22]],"date-time":"2005-06-22T13:41:40Z","timestamp":1119447700000},"page":"415-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pulmonary eosinophilia in sudden infant death syndrome"],"prefix":"10.1002","volume":"177","author":[{"given":"Julia A.","family":"Baxendine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella E.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,15]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Office of Population Censuses and Surveys. Monitor. Sudden Infant Deaths 1988\u201392. 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