{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:08:11Z","timestamp":1782234491460,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T00:00:00Z","timestamp":1106870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mucosa\u2010associated lymphoid tissue (MALT) lymphoma is specifically associated with t(11;18)(q21;q21), t(1;14)(p22;q32) and t(14;18)(q32;q21). t(11;18)(q21;q21) fuses the N\u2010terminus of the <jats:italic>API2<\/jats:italic> gene to the C\u2010terminus of the <jats:italic>MALT1<\/jats:italic> gene and generates a functional API2\u2010MALT1 product. t(1;14)(p22;q32) and t(14;18)(q32;q21) bring the <jats:italic>BCL10<\/jats:italic> and <jats:italic>MALT1<\/jats:italic> genes respectively to the <jats:italic>IGH<\/jats:italic> locus and deregulate their expression. The oncogenic activity of the three chromosomal translocations is linked by the physiological role of BCL10 and MALT1 in antigen receptor\u2010mediated NF\u03baB activation. In this study, MALT1 and BCL10 expression was examined in normal lymphoid tissues and 423 cases of MALT lymphoma from eight sites, and their expression was correlated with the above translocations, which were detected by molecular and molecular cytogenetic methods. In normal B\u2010cell follicles, both MALT1 and BCL10 were expressed predominantly in the cytoplasm, high in centroblasts, moderate in centrocytes and weak\/negative in mantle zone B\u2010cells. In MALT lymphoma, MALT1 and BCL10 expression varied among cases with different chromosomal translocations. In 9\/9 MALT lymphomas with t(14;18)(q32;q21), tumour cells showed strong homogeneous cytoplasmic expression of both MALT1 and BCL10. In 12\/12 cases with evidence of t(1;14)(p22;q32) or variants, tumour cells expressed MALT1 weakly in the cytoplasm but BCL10 strongly in the nuclei. In all 67 MALT lymphomas with t(11;18)(q21;q21), tumour cells expressed weak cytoplasmic MALT1 and moderate nuclear BCL10. In MALT lymphomas without the above translocations, both MALT1 and BCL10, in general, were expressed weakly in the cytoplasm. Real\u2010time quantitative RT\u2010PCR showed a good correlation between <jats:italic>MALT1<\/jats:italic> and <jats:italic>BCL10<\/jats:italic> mRNA expression and underlining genetic changes, with t(14;18)(q32;q21)\u2010 and t(1;14)(p22;q32)\u2010positive cases displaying the highest <jats:italic>MALT1<\/jats:italic> and <jats:italic>BCL10<\/jats:italic> mRNA expression respectively. These results show that MALT1 expression pattern is identical to that of BCL10 in normal lymphoid tissues but varies in MALT lymphomas, with high cytoplasmic expression of both MALT1 and BCL10 characterizing those with t(14;18)(q32;q21). Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1715","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T09:46:31Z","timestamp":1106905591000},"page":"293-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["MALT lymphoma with t(14;18)(q32;q21)\/<i>IGH\u2010MALT1<\/i> is characterized by strong cytoplasmic MALT1 and BCL10 expression"],"prefix":"10.1002","volume":"205","author":[{"given":"Hongtao","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifat 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