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Recent studies have demonstrated that CDX2 regulates <jats:italic>LI\u2010cadherin<\/jats:italic> gene (<jats:italic>CDH17<\/jats:italic>) expression in colorectal cancer. The present study investigated the relationship of CDX2 and LI\u2010cadherin expression in gastric cancer. One hundred and nine pairs of tumour and non\u2010cancerous gastric mucosa were collected from gastrectomy specimens. Protein expression levels of CDX2 and LI\u2010cadherin were determined by immunohistochemical staining. Semi\u2010quantitative RT\u2010PCR showed that the mRNAs of both <jats:italic>CDX2<\/jats:italic> and <jats:italic>CDH17<\/jats:italic> were highly expressed in tumour compared with non\u2010cancerous mucosa. Overexpression of <jats:italic>CDX2<\/jats:italic> was significantly associated with <jats:italic>CDH17<\/jats:italic> in gastric adenocarcinoma. Furthermore, the expression of CDX2 and LI\u2010cadherin proteins was strongly coupled in intestinal metaplasia. In conclusion, overexpression of <jats:italic>CDH17<\/jats:italic> is significantly associated with <jats:italic>CDX2<\/jats:italic>. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1741","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T09:48:20Z","timestamp":1109238500000},"page":"615-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["CDX2 co\u2010localizes with liver\u2013intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach"],"prefix":"10.1002","volume":"205","author":[{"given":"Samuel","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent\u2010Man","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Moon\u2010Ching","family":"Luk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie Wing\u2010Yan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu\u2010Tsan","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suet\u2010Yi","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.44.1.7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(93)90029-P"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/32433"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.808"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.078"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.125.6.1353"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.1146"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05236.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.5.1109"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.197"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.73"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36598"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90471-N"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74240-9"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36596-1"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1995.1132"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-1809.1997.6150393.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7318"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.18142"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1139\/o99-001"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202280"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1246"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31902"},{"key":"e_1_2_6_25_2","volume-title":"Japanese Research Society for Gastric Cancer. 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