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However, <jats:italic>in situ<\/jats:italic> studies of AID expression have until now been hampered by a lack of antibodies suitable for immunohistochemistry. To overcome this problem, an AID\u2010specific monoclonal antibody suitable for immunohistochemical staining of formalin\u2010fixed, paraffin wax\u2010embedded tissue sections has been generated. This antibody was shown to detect AID expression in normal germinal centre B\u2010cells as well as in non\u2010Hodgkin lymphomas with a putative germinal centre origin. Using this antibody, a virtually exclusive cytoplasmic localization of AID in normal and neoplastic B\u2010cells is shown. Employing a combination of immunohistochemistry and AID\u2010specific <jats:italic>in situ<\/jats:italic> hybridization, it is demonstrated that AID is consistently expressed in the neoplastic cells of nodular lymphocyte\u2010predominant Hodgkin lymphoma (HLnlp) but only infrequently in classical HL (cHL). This is in keeping with the notion that tumour cells of HLnlp represent transformed germinal centre B\u2010cells showing evidence of somatic hypermutation. AID represents an additional marker useful in the differential diagnosis of HLnlp and cHL. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1746","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T09:48:48Z","timestamp":1109238528000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Differential expression of activation\u2010induced cytidine deaminase (AID) in nodular lymphocyte\u2010predominant and classical Hodgkin 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