{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:28:36Z","timestamp":1790368116328,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T00:00:00Z","timestamp":1110931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An important feature of chronic obstructive pulmonary disease (COPD) is airway remodelling, the molecular mechanisms of which are poorly understood. In this study, the role of fibroblast growth factors (FGF\u20101 and FGF\u20102) and their receptor, FGFR\u20101, was assessed in bronchial airway wall remodelling in patients with COPD (FEV<jats:sub>1<\/jats:sub> &lt; 75%; <jats:italic>n<\/jats:italic> = 15) and without COPD (FEV<jats:sub>1<\/jats:sub> &gt; 85%; <jats:italic>n<\/jats:italic> = 16). FGF\u20101 and FGFR\u20101 were immunolocalized in bronchial epithelium, airway smooth muscle (ASM), submucosal glandular epithelium, and vascular smooth muscle. Quantitative digital image analysis revealed increased cytoplasmic expression of FGF\u20102 in bronchial epithelium (0.35 \u00b1 0.03 vs 0.20 \u00b1 0.04, <jats:italic>p<\/jats:italic> &lt; 0.008) and nuclear localization in ASM (<jats:italic>p<\/jats:italic> &lt; 0.0001) in COPD patients compared with controls. Elevated levels of FGFR\u20101 in ASM (<jats:italic>p<\/jats:italic> &lt; 0.005) and of FGF\u20101 (<jats:italic>p<\/jats:italic> &lt; 0.04) and FGFR\u20101 (<jats:italic>p<\/jats:italic> &lt; 0.001) in bronchial epithelium were observed. In cultured human ASM cells, FGF\u20101 and\/or FGF\u20102 (10 ng\/ml) induced cellular proliferation, as shown by [<jats:sup>3<\/jats:sup>H]thymidine incorporation and by cell number counts. Steady\u2010state mRNA levels of FGFR\u20101 were elevated in human ASM cells treated with either FGF\u20101 or FGF\u20102. The increased bronchial expression of fibroblast growth factors and their receptor in patients with COPD, and the mitogenic response of human ASM cells to FGFs <jats:italic>in vitro<\/jats:italic> suggest a potential role for the FGF\/FGFR\u20101 system in the remodelling of bronchial airways in COPD. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1748","type":"journal-article","created":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T10:47:01Z","timestamp":1110970021000},"page":"28-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Chronic obstructive pulmonary disease is associated with enhanced bronchial expression of FGF\u20101, FGF\u20102, and FGFR\u20101"],"prefix":"10.1002","volume":"206","author":[{"given":"Andor R","family":"Kranenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Willems\u2010Widyastuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolter J","family":"Mooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod 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