{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:15:44Z","timestamp":1792199744236,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T00:00:00Z","timestamp":1110931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>PRDM1\/Blimp\u20101 (in human and mouse, respectively) has a central role in determining and shaping the secretory arm of mature B\u2010cell differentiation. In this study, a mouse monoclonal antibody that recognizes PRDM1 was used to detail its distribution in normal human lymphoid tissue and in lymphoid neoplasms that correspond to different stages of B\u2010cell differentiation. PRDM1 was expressed in germinal centre blasts that co\u2010express Pax5, CD19, CD20, and CD10, but not BCL6 or MTA\u20103. Pax5 was downregulated and full plasma cell morphology and phenotype were acquired by PRDM1<jats:sup>+<\/jats:sup>, nuclear cREL<jats:sup>\u2212<\/jats:sup>, pre\u2010plasma cells upon exit from the germinal centre. Activated extrafollicular B\u2010cells (CD30<jats:sup>+<\/jats:sup>, Pax5<jats:sup>+<\/jats:sup>) were largely PRDM1<jats:sup>\u2212<\/jats:sup>. PRDM1 was also absent in tissue histiocytes and the majority of resting T\u2010cells and S\u2010100<jats:sup>+<\/jats:sup> antigen\u2010presenting cells. PRDM1 and CD138 were expressed simultaneously in human lymphomas with plasma cell differentiation, but not in marginal zone lymphomas or chronic lymphocytic leukaemias. A minority of diffuse large B\u2010cell lymphomas expressed PRDM1 and Hodgkin lymphomas were largely PRDM1<jats:sup>\u2212<\/jats:sup>. Infiltrating T\u2010cells in PRDM1<jats:sup>\u2212<\/jats:sup> B\u2010cell lymphomas expressed PRDM1. In conclusion, PRDM1 staining is a reliable and informative assay to define plasma cell commitment and differentiation in human normal and neoplastic B\u2010cell lineages. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1752","type":"journal-article","created":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T15:27:16Z","timestamp":1110986836000},"page":"76-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["PRDM1\/Blimp\u20101 is expressed in human B\u2010lymphocytes committed to the plasma cell lineage"],"prefix":"10.1002","volume":"206","author":[{"given":"Giorgio","family":"Cattoretti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Angelin\u2010Duclos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Shaknovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Alobeid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35085679"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00335-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.10.5462"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1158"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.2.611"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200107)31:7<1972::AID-IMMU1972>3.0.CO;2-T"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5312.596"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.06.010"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0304-241"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00189-2"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/77861"},{"key":"e_1_2_6_13_2","volume-title":"Post\u2010transplant Lymphoproliferative Disorders","author":"Harris NL","year":"2001"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-0492-NRDFTM"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4291"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316624"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.13.4771-4780.2002"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1359"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.1.45.bloodjournal86145"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711680404"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711710205"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.2084"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0750"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00109-1"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-199703000-00010"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00022744-199903000-00013"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190313"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/44.12.8985127"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb06978.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19960615)26:2<137::AID-CYTO7>3.0.CO;2-D"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.014"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437996100"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.4.848.848"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.11.1625"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00267-X"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040973"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067518"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80578-6"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2673"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1737"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830211105"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.282"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.9.3108"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.4.1495"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1197"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf389"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020062"},{"key":"e_1_2_6_49_2","volume-title":"Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0839"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.3.451"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3355"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1752","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:29:19Z","timestamp":1761053359000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,16]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1002\/path.1752"],"URL":"https:\/\/doi.org\/10.1002\/path.1752","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,16]]},"assertion":[{"value":"2004-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-12-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}