{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T19:22:24Z","timestamp":1794338544757,"version":"4.9.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T00:00:00Z","timestamp":1114387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although human papillomavirus (HPV) DNA is detected in the majority of squamous intraepithelial lesions (SILs) and squamous cell carcinomas (SCCs) of the uterine cervix, the persistence and progression of cervical lesions suggest that viral antigens are not adequately presented to the immune system. This hypothesis is reinforced by the observation that most SILs show quantitative and functional alterations of Langerhans cells (LCs). The aim of this study was to determine whether modulation of E\u2010cadherin\u2010mediated homophilic and heterotypic interactions between keratinocytes and LCs is involved in these abnormalities of LCs in (pre)neoplastic cervical epithelium. Cell membrane expression of E\u2010cadherin and the density of CD1a\n                    <jats:sup>+<\/jats:sup>\n                    LCs were low in the epithelium of SILs and SCC biopsy specimens, compared with normal exocervical epithelium. Dendritic cells (DCs) and LCs generated\n                    <jats:italic>in vitro<\/jats:italic>\n                    were randomly distributed throughout the full thickness of organotypic cultures of E\u2010cadherin\n                    <jats:sup>\u2212<\/jats:sup>\n                    HPV\u2010transformed cells. In contrast, these cells rapidly adhered to the keratinocyte cell layers when HPV\u2010transformed cells transfected with E\u2010cadherin were used. These data suggest that the E\u2010cadherin\u2010mediated contact between keratinocytes and LCs is potentially important for initiating or maintaining the immune response during chronic HPV infection. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1771","type":"journal-article","created":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T08:16:41Z","timestamp":1114417001000},"page":"346-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["E\u2010cadherin\u2010dependent adhesion of dendritic and Langerhans cells to keratinocytes is defective in cervical human papillomavirus\u2010associated (pre)neoplastic 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