{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:30:55Z","timestamp":1791228655426,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:00:00Z","timestamp":1115683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphoma (MCL) is associated with a very unfavourable clinical course. This is particularly true for mantle cell lymphoma of the blastoid subtype (MCL\u2010b). In order to define prognostic factors, we analysed the impact of immunoglobulin heavy chain variable (\n                    <jats:italic>IgV<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>H<\/jats:italic>\n                    <\/jats:sub>\n                    ) gene somatic hypermutations on clinical outcome in a series of 21 cases of morphologically, phenotypically, and genotypically well\u2010characterized MCL\u2010b. Testing and estimation were performed using log\u2010rank statistics and displayed on Kaplan\u2013Meier graphs. Thirteen of 21 cases of MCL\u2010b revealed a homology rate of \u226599% compared to\n                    <jats:italic>IgV<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>H<\/jats:italic>\n                    <\/jats:sub>\n                    germ\u2010line sequences in the databases and were scored as non\u2010mutated. Eight of 21 cases (38%) of MCL\u2010b were mutated. In MCL\u2010b the mutation frequency was usually low and the mutation pattern was only rarely antigen\u2010selected, in contrast to a control group of 11 cases with morphologically almost identical, but phenotypically and genotypically clearly distinguishable, diffuse large B cell lymphoma, derived, most likely, from germinal centre B cells. In our series of 21 MCL\u2010b, positive\n                    <jats:italic>IgV<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>H<\/jats:italic>\n                    <\/jats:sub>\n                    mutational status, irrespective of varying homology thresholds, had no statistically significant prognostic impact on event\u2010free or overall survival. However, mutated MCL\u2010b tended to present more frequently at an earlier stage and without bone marrow involvement and to show lower rates of relapse and death, resulting in a more favourable clinical outcome. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1781","type":"journal-article","created":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T14:24:01Z","timestamp":1115735041000},"page":"320-327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<i>IgV<\/i>\n                    <sub>\n                      <i>H<\/i>\n                    <\/sub>\n                    mutations in blastoid mantle cell lymphoma characterize a subgroup with a tendency to more favourable clinical outcome"],"prefix":"10.1002","volume":"206","author":[{"given":"Sergio B","family":"Cogliatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter R","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Henz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim C","family":"Diss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ghielmini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrico","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"406","article-title":"Classification of non\u2010Hodgkin's lymphomas [Letter to the Editor]","author":"G\u00e9rard\u2010Marchant R","year":"1974","journal-title":"Lancet"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.6.1617.1617"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199207000-00001"},{"key":"e_1_2_6_5_2","volume-title":"World Health Organization Classification of Tumours. 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