{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:04:06Z","timestamp":1791201846745,"version":"4.2.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T00:00:00Z","timestamp":1118707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunohistochemical analysis of E\u2010cadherin has changed the way lobular neoplasia is perceived. It has helped to classify difficult cases of carcinoma <jats:italic>in situ<\/jats:italic> with indeterminate features and led to the identification of new variants of lobular carcinoma. Pleomorphic lobular carcinoma (PLC) and pleomorphic lobular carcinoma <jats:italic>in situ<\/jats:italic> (PLCIS), recently described variants of invasive and <jats:italic>in situ<\/jats:italic> classic lobular carcinoma, are reported to be associated with more aggressive clinical behaviour. Although PLC\/PLCIS show morphological features of classic lobular neoplasia and lack E\u2010cadherin expression, it is still unclear whether these lesions evolve through the same genetic pathway as lobular carcinomas or are high\u2010grade ductal neoplasms that have lost E\u2010cadherin. Here we have analysed a case of extensive PLCIS and invasive PLC associated with areas of E\u2010cadherin\u2010negative carcinoma <jats:italic>in situ<\/jats:italic> with indeterminate features, using immunohistochemistry, chromogenic <jats:italic>in situ<\/jats:italic> hybridization, high\u2010resolution comparative genomic hybridization (CGH) and array\u2010based CGH. We observed that all lesions lacked E\u2010cadherin and \u03b2\u2010catenin and showed gain of 1q and loss of 16q, features that are typical of lobular carcinomas but are not seen in high\u2010grade ductal lesions. In addition, amplifications of <jats:italic>c\u2010myc<\/jats:italic> and <jats:italic>HER2<\/jats:italic> were detected in the pleomorphic components, which may account for the high\u2010grade features in this case and the reported aggressive clinical behaviour of these lesions. Taken together, these data suggest that at least some PLCs may evolve from the same precursor or through the same genetic pathway as classic lobular carcinomas. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1806","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T10:16:22Z","timestamp":1118744182000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity"],"prefix":"10.1002","volume":"207","author":[{"given":"Jorge S","family":"Reis\u2010Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete T","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Iravani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Fenwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haukur","family":"Valgeirsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryou","family":"Lambros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ashworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil R","family":"Lakhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1691"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr650"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr624"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000030450.20581.E3"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200102000-00012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2003.10.009"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1309\/B0DD-4M7H-GJG1-7KCW"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200102000-00011"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199903)187:4<396::AID-PATH286>3.0.CO;2-L"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<521::AID-PATH472>3.0.CO;2-B"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20070"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971021)74:5<513::AID-IJC6>3.0.CO;2-6"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.22759"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20273"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200012000-00009"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000073974.42583.F7"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80053-2"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90321-S"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90035-2"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1530"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157295.93914.3b"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0731"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1847304"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth418"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1992"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64785-2"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2003.11.009"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800362"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1208"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1326"},{"key":"e_1_2_6_32_2","first-page":"118","article-title":"Pleomorphic apocrine lobular carcinoma in situ (PALCIS): phenotypic and genetic study of a distinct variant of lobular carcinoma in situ (LCIS)","volume":"18","author":"Chen Y","year":"2005","journal-title":"Mod Pathol"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0165"},{"key":"e_1_2_6_34_2","first-page":"4721","article-title":"Comparative genomic hybridization analysis of lobular carcinoma in situ and atypical lobular hyperplasia and potential roles for gains and losses of genetic material in breast neoplasia","volume":"58","author":"Lu YJ","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11197"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207439"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1385"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1806","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:17:15Z","timestamp":1761049035000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,14]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1002\/path.1806"],"URL":"https:\/\/doi.org\/10.1002\/path.1806","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,14]]},"assertion":[{"value":"2005-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}