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The aims of the present study were to identify putative differences in gene expression between solitary and Ollier disease\u2010related tumours, and to elucidate signalling pathways involved in tumour progression by genome\u2010wide cDNA expression analysis. Arrays enriched for cartilage\u2010specific cDNAs and genes involved in general tumourigenesis were used to analyse enchondromas (<jats:italic>n<\/jats:italic> = 3, two with Ollier disease), chondrosarcomas of different grades (<jats:italic>n<\/jats:italic> = 19, three with Ollier disease), normal resting\u2010zone cartilage (<jats:italic>n<\/jats:italic> = 2), and chondrosarcoma cells in culture (<jats:italic>n<\/jats:italic> = 7). The arrays were analysed by unsupervised hierarchical clustering, significant analysis of microarray, and <jats:italic>T<\/jats:italic>\u2010tests. Confirmation of data was performed by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction (RT\u2010PCR). Ollier disease cases and solitary tumours revealed similar expression profiles, suggesting that the same signalling pathways are involved in tumourigenesis. Interestingly, JunB protein expression was significantly higher in grade I chondrosarcomas than in enchondromas (<jats:italic>p<\/jats:italic> = 0.009), which could be of diagnostic relevance. Upon chondrosarcoma progression, matrix\u2010associated genes are down\u2010regulated, reflecting the histology of high\u2010grade tumours. An increase in glycolysis\u2010associated, and a decrease in oxidative phosphorylation\u2010related, genes was found in high\u2010grade tumours. These findings suggest an adaptation in energy supply upon progression towards higher grade. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1813","type":"journal-article","created":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T12:24:55Z","timestamp":1120825495000},"page":"61-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["cDNA expression profiling of chondrosarcomas: Ollier disease resembles solitary tumours and alteration in genes coding for components of energy metabolism occurs with increasing grade"],"prefix":"10.1002","volume":"207","author":[{"given":"Leida B","family":"Rozeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Hameetman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van Wezel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonie HM","family":"Taminiau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Cleton\u2010Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pancras CW","family":"Hogendoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith VMG","family":"Bov\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,8]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"247","volume-title":"World Health Organization Classification of Tumours. 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