{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:41:45Z","timestamp":1761050505854,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,7,12]],"date-time":"2005-07-12T00:00:00Z","timestamp":1121126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Activating germline mutations in the fibroblast growth factor receptor (FGFR) gene family have been identified in several dominantly inherited skeletal disorders; in the case of <jats:italic>FGFR3<\/jats:italic>, the same somatically arising mutations have also been isolated from a variety of tumour tissues. Whilst the role of <jats:italic>FGFR2<\/jats:italic> mutations in congenital syndromes has been well documented, their relationship with cancer has not been clearly defined. Based on evidence that gain\u2010of\u2010function mutations in <jats:italic>FGFR2<\/jats:italic> drive positive selection in adult spermatogonia, the present study investigated, by denaturing high\u2010performance liquid chromatography (DHPLC), DNA sequencing, and restriction digestion, the prevalence of <jats:italic>FGFR2<\/jats:italic> mutations in 58 tumour cell lines of various types, and 29 testicular germ cell tumour samples. Although sequence variations and allelic imbalance were identified in <jats:italic>FGFR2<\/jats:italic>, none of the previously documented dominant mutations was detected in any of the tumour types examined. This suggests that gain\u2010of\u2010function <jats:italic>FGFR2<\/jats:italic> mutations are not commonly encountered in tumourigenesis and specifically excludes a major contribution in testicular tumours. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1816","type":"journal-article","created":{"date-parts":[[2005,7,12]],"date-time":"2005-07-12T06:16:22Z","timestamp":1121148982000},"page":"27-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fibroblast growth factor receptor 2, gain\u2010of\u2010function mutations, and tumourigenesis: investigating a potential link"],"prefix":"10.1002","volume":"207","author":[{"given":"Ruth MS","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Goriely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian 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