{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:28:32Z","timestamp":1775165312323,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,9,23]],"date-time":"2005-09-23T00:00:00Z","timestamp":1127433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Host response plays a major role in the pathogenesis of <jats:italic>Helicobacter pylori<\/jats:italic>\u2010induced gastroduodenal disease including adenocarcinoma of the distal stomach. Vascular endothelial growth factor (VEGF) is an important modulator of gastric mucosal repair and is overexpressed in gastric cancer. The present study sought to evaluate the expression of VEGF in the gastric mucosa of <jats:italic>H. pylori<\/jats:italic>\u2010infected and <jats:italic>H. pylori<\/jats:italic>\u2010non\u2010infected dyspeptic patients. Fifteen <jats:italic>H. pylori<\/jats:italic>\u2010infected and 15 <jats:italic>H. pylori<\/jats:italic>\u2010non\u2010infected dyspeptic patients were studied. Diagnosis of <jats:italic>H. pylori<\/jats:italic> infection was based on rapid urease test and histology. VEGF protein expression was assessed by western blotting. VEGF mRNA expression was assessed by RT\u2010PCR. VEGF localization in the gastric mucosa and neo\u2010angiogenesis were determined by immunohistochemistry. VEGF protein and mRNA expression was significantly greater in <jats:italic>H. pylori<\/jats:italic>\u2010infected than in non\u2010infected patients. Immunohistochemistry showed that VEGF expression was more intense in the gastric gland compartment of <jats:italic>H. pylori<\/jats:italic>\u2010infected mucosa than in the non\u2010infected mucosa. The increase in VEGF expression was associated with a significant increase in neo\u2010angiogenesis as assessed by determination of CD34\u2010positive micro\u2010vessels. <jats:italic>H. pylori<\/jats:italic> gastritis is therefore associated with up\u2010regulation of VEGF expression, which parallels the increased formation of blood vessels in the gastric mucosa. It is postulated that increased VEGF expression and neo\u2010angiogenesis may contribute to <jats:italic>H. pylori<\/jats:italic>\u2010related gastric carcinogenesis. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1844","type":"journal-article","created":{"date-parts":[[2005,9,23]],"date-time":"2005-09-23T11:16:28Z","timestamp":1127474188000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Vascular endothelial growth factor and neo\u2010angiogenesis in <i>H. pylori<\/i> gastritis in humans"],"prefix":"10.1002","volume":"207","author":[{"given":"Concetta","family":"Tuccillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Cuomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Staibano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mascolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta G","family":"Gravina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Nardone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fortunato","family":"Ciardiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillo","family":"Del Vecchio Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/314785"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.1999.00018.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80051-2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/35073084"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc703"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00389.2001"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2741\/A428"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114322"},{"key":"e_1_2_6_10_2","first-page":"4727","article-title":"Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract","volume":"53","author":"Brown LF","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5409"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03940.x"},{"key":"e_1_2_6_13_2","first-page":"2015","article-title":"Helicobacter pylori VacA toxin up\u2010regulates vascular endothelial growth factor expression in MKN 28 gastric cells through an epidermal growth factor receptor\u2010, cyclooxygenase\u20102\u2010dependent mechanism","volume":"9","author":"Caputo R","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1200906"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80108-6"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.03376.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99049-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1512"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2004.tb00474.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70422-6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.64.7.2829-2833.1996"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(03)00211-7"},{"key":"e_1_2_6_26_2","first-page":"951","article-title":"Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin","volume":"63","author":"Cover TL","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10254-004-0027-3"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.12.863"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116132"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613050"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000048835"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90087-X"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240501120"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.054"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0055fje"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS103S450S"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000030089.76514.e4"},{"key":"e_1_2_6_38_2","first-page":"17","article-title":"Influence of gastrin on the expression of cyclooxygenase\u20102, hepatocyte growth factor and apoptosis\u2010related proteins in gastric epithelial cells","volume":"54","author":"Konturek PC","year":"2003","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0015"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11373-004-8177-5"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1174"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.44.28560"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0302-289"},{"key":"e_1_2_6_44_2","first-page":"581","article-title":"Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells","volume":"39","author":"Cheng T","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/70995"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.07.025"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011665"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/79664"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.1268.11.3"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1844","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:35:33Z","timestamp":1761064533000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,23]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["10.1002\/path.1844"],"URL":"https:\/\/doi.org\/10.1002\/path.1844","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,23]]},"assertion":[{"value":"2005-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}