{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:20:21Z","timestamp":1773242421303,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,8]],"date-time":"2005-11-08T00:00:00Z","timestamp":1131408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intestinal metaplasia (IM) is a preneoplastic lesion of the stomach in which there is transdifferentiation of the gastric mucosa to an intestinal phenotype. The\n                    <jats:italic>caudal<\/jats:italic>\n                    \u2010related homeobox gene\n                    <jats:italic>CDX2<\/jats:italic>\n                    encodes an intestine\u2010specific transcription factor crucial for the regulation of proliferation and differentiation of intestinal cells. In addition, CDX2 is involved in the induction of IM in the stomach. The aim of this study was to access the putative involvement of OCT\u20101 in the induction of CDX2 expression\n                    <jats:italic>de novo<\/jats:italic>\n                    in gastric mucosa leading to the onset of IM. OCT\u20101 protein expression was evaluated by immunohistochemistry in 31 biopsies with chronic gastritis, 15 biopsies with foci of IM and adjacent gastric mucosa and 42 gastric carcinomas. Furthermore, we evaluated OCT\u20101 binding by electrophoretic mobility shift assay and activation of the\n                    <jats:italic>CDX2<\/jats:italic>\n                    promoter by co\u2010transfecting a\n                    <jats:italic>CDX2<\/jats:italic>\n                    promoter\/reporter construct with an OCT\u20101 expression vector in two gastric carcinoma cell lines, GP220 and MKN45. Our results show that OCT\u20101 is expressed in chronic gastritis, particularly when it is adjacent to IM and is expressed in 87% of IM foci. Furthermore, 74% of the gastric carcinomas were positive for OCT\u20101 and a strong association was observed between OCT\u20101 expression and intestinal\u2010type carcinoma. We identified that OCT\u20101 binds to the\n                    <jats:italic>CDX2<\/jats:italic>\n                    promoter, although we could not see a transactivation effect in gastric carcinoma cell lines. In conclusion, we observed increased OCT\u20101 expression in IM and in intestinal gastric carcinomas and identified the capacity of OCT\u20101 to bind to the\n                    <jats:italic>CDX2<\/jats:italic>\n                    promoter, although we could not demonstrate a direct effect of OCT\u20101 in the transactivation of\n                    <jats:italic>CDX2<\/jats:italic>\n                    . Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1861","type":"journal-article","created":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T13:55:12Z","timestamp":1132149312000},"page":"396-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["OCT\u20101 is over\u2010expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells"],"prefix":"10.1002","volume":"207","author":[{"given":"Raquel","family":"Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Shoshkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Mesquita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabete","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Van Seuningen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso A","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filipe","family":"Santos\u2010Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,8]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process. 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