{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:48:53Z","timestamp":1791139733149,"version":"4.1.0"},"reference-count":206,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,17]],"date-time":"2005-12-17T00:00:00Z","timestamp":1134777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic gastritis induced by\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a minority of people who harbour this organism ever develop cancer.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    isolates possess substantial genotypic diversity, which engenders differential host inflammatory responses that influence clinical outcome.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    strains that possess the\n                    <jats:italic>cag<\/jats:italic>\n                    pathogenicity island and secrete a functional cytotoxin induce more severe gastric injury and further augment the risk for developing distal gastric cancer. However, carcinogenesis is also influenced by host genetic diversity, particularly involving immune response genes such as\n                    <jats:italic>IL\u20101\u00df<\/jats:italic>\n                    and\n                    <jats:italic>TNF\u2010<\/jats:italic>\n                    \u03b1. It is important to gain insight into the pathogenesis of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010induced gastritis and adenocarcinoma, not only to develop more effective treatments for gastric cancer, but also because it might serve as a paradigm for the role of chronic inflammation in the genesis of other malignancies that arise within the gastrointestinal tract. Copyright \u00a9 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1868","type":"journal-article","created":{"date-parts":[[2005,12,17]],"date-time":"2005-12-17T13:46:30Z","timestamp":1134827190000},"page":"233-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":455,"title":["<i>Helicobacter<\/i>\n                    infection and gastric neoplasia"],"prefix":"10.1002","volume":"208","author":[{"suffix":"Jr","given":"Richard M","family":"Peek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean E","family":"Crabtree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc703"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.039834"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70131-X"},{"key":"e_1_2_6_6_2","first-page":"477","article-title":"Helicobacter pylori and gastric cancer: state of the art","volume":"5","author":"Correa P","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1703"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90474-Y"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.302.6788.1302"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251604"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018833819860"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709028150"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.4.319"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90954-B"},{"key":"e_1_2_6_16_2","first-page":"1806","article-title":"Association of Helicobacter pylori with gastric cancer and observations on the detection of this bacterium in gastric cancer cases","volume":"89","author":"Hu PJ","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950615)75:12<2789::AID-CNCR2820751202>3.0.CO;2-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609009143"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02934482"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971210)73:6<837::AID-IJC12>3.0.CO;2-1"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.347"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10887"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/41483"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/16495"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.13.3934-3938.1996"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14668"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251551698"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14648"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00770.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.58.3.603-610.1990"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90477-7"},{"key":"e_1_2_6_33_2","first-page":"760","article-title":"Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains","volume":"73","author":"Peek RM","year":"1995","journal-title":"Lab Invest"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.1.28-32.1995"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.23.1777"},{"key":"e_1_2_6_36_2","first-page":"645","article-title":"Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection","volume":"8","author":"Beales IL","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.10.1339"},{"key":"e_1_2_6_38_2","first-page":"2111","article-title":"Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach","volume":"55","author":"Blaser MJ","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018849112533"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981005)78:2<135::AID-IJC1>3.0.CO;2-#"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<298::AID-IJC6>3.0.CO;2-Q"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199801000-00008"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.3.225"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70122-8"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14559"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1497"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.3.1263"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.593"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2000.00043.x"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100754200"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02781.x"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067147"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222375399"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208155200"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309964200"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107630200"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.066977"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00740-4"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.5.3629"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2003.11.005"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.10.5552"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2004.00366.x"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg050"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081919"},{"key":"e_1_2_6_66_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200208039"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.10.967"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.2346-2348.1998"},{"key":"e_1_2_6_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.3893-3899.1999"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.44.31655"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.9.653"},{"key":"e_1_2_6_72_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000959200"},{"key":"e_1_2_6_73_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02714.x"},{"key":"e_1_2_6_74_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.10.945"},{"key":"e_1_2_6_75_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.1.41"},{"key":"e_1_2_6_76_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.5.1681-1687.1995"},{"key":"e_1_2_6_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90009-8"},{"key":"e_1_2_6_78_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8964399"},{"key":"e_1_2_6_79_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.10.765"},{"key":"e_1_2_6_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1131"},{"key":"e_1_2_6_81_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182558799"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.11.6970-6980.2001"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1086\/424526"},{"key":"e_1_2_6_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50054-0"},{"key":"e_1_2_6_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34097-8"},{"key":"e_1_2_6_86_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.5.1653"},{"key":"e_1_2_6_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01019.x"},{"key":"e_1_2_6_88_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.5.1557-1565.1994"},{"key":"e_1_2_6_89_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-26-2-93"},{"key":"e_1_2_6_90_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17771"},{"key":"e_1_2_6_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.9.2597-2603.1998"},{"key":"e_1_2_6_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70065-X"},{"key":"e_1_2_6_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12778"},{"key":"e_1_2_6_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000801)87:3<322::AID-IJC3>3.0.CO;2-M"},{"key":"e_1_2_6_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03685.x"},{"key":"e_1_2_6_96_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2001.00044.x"},{"key":"e_1_2_6_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70223-3"},{"key":"e_1_2_6_98_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.10.4154-4160.1995"},{"key":"e_1_2_6_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1112"},{"key":"e_1_2_6_100_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2808"},{"key":"e_1_2_6_101_2","first-page":"6124","article-title":"Helicobacter pylori strain\u2010specific genotypes and modulation of the gastric epithelial cell cycle","volume":"59","author":"Peek RM","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_102_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.23.6361"},{"key":"e_1_2_6_103_2","first-page":"951","article-title":"Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin","volume":"63","author":"Cover TL","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_104_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304131200"},{"key":"e_1_2_6_105_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2764"},{"key":"e_1_2_6_106_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307520"},{"key":"e_1_2_6_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-1418-9_19"},{"key":"e_1_2_6_108_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086871"},{"key":"e_1_2_6_109_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030621"},{"key":"e_1_2_6_110_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401528101"},{"key":"e_1_2_6_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2005.04.002"},{"key":"e_1_2_6_112_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.63.3.675-707.1999"},{"key":"e_1_2_6_113_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308573100"},{"key":"e_1_2_6_114_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.373"},{"key":"e_1_2_6_115_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069076"},{"key":"e_1_2_6_116_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412725200"},{"key":"e_1_2_6_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.02.013"},{"key":"e_1_2_6_118_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199504000-00010"},{"key":"e_1_2_6_119_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1130"},{"key":"e_1_2_6_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92816-X"},{"key":"e_1_2_6_121_2","first-page":"375","article-title":"Host mechanisms: are they the key to various clinical outcomes in Helicobacter pylori infection?","volume":"29","author":"Calam J","year":"1997","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"e_1_2_6_122_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.227"},{"key":"e_1_2_6_123_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9024290"},{"key":"e_1_2_6_124_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1473"},{"key":"e_1_2_6_125_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37043"},{"key":"e_1_2_6_126_2","first-page":"G783","article-title":"Mononuclear cells and cytokines stimulate gastrin release from canine antral G cells in primary culture","volume":"270","author":"Lehmann FS","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_6_127_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2135193100"},{"key":"e_1_2_6_128_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8536851"},{"key":"e_1_2_6_129_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9247465"},{"key":"e_1_2_6_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70228-2"},{"key":"e_1_2_6_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70531-1"},{"key":"e_1_2_6_132_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1498"},{"key":"e_1_2_6_133_2","first-page":"A215","article-title":"H. pylori\u2010induced hypergastrinaemia is related to bacterial CagA status","volume":"112","author":"McColl KEL","year":"1997","journal-title":"Gastroenterology"},{"key":"e_1_2_6_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70413-6"},{"key":"e_1_2_6_135_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11450"},{"key":"e_1_2_6_136_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.119"},{"key":"e_1_2_6_137_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.064"},{"key":"e_1_2_6_138_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI20925"},{"key":"e_1_2_6_139_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.053"},{"key":"e_1_2_6_140_2","doi-asserted-by":"publisher","DOI":"10.1086\/515606"},{"key":"e_1_2_6_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70143-X"},{"key":"e_1_2_6_142_2","first-page":"4255","article-title":"Development of Helicobacter pylori\u2010induced gastric carcinoma in Mongolian gerbils","volume":"58","author":"Honda S","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_143_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00743.x"},{"key":"e_1_2_6_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03469.x"},{"key":"e_1_2_6_145_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504927102"},{"key":"e_1_2_6_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70412-4"},{"key":"e_1_2_6_147_2","first-page":"942","article-title":"Helicobacter pylori\u2010associated gastric cancer in INS\u2010GAS mice is gender specific","volume":"63","author":"Fox JG","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_6_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00406-2"},{"key":"e_1_2_6_149_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.027"},{"key":"e_1_2_6_150_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.827"},{"key":"e_1_2_6_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208407"},{"key":"e_1_2_6_152_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.066"},{"key":"e_1_2_6_153_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099513"},{"key":"e_1_2_6_154_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.2035"},{"key":"e_1_2_6_155_2","doi-asserted-by":"publisher","DOI":"10.1038\/75015"},{"key":"e_1_2_6_156_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00049.2002"},{"key":"e_1_2_6_157_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.01.005"},{"key":"e_1_2_6_158_2","article-title":"Helicobacter pylori and Schistosoma japonicum co\u2010infection in a Chinese population: helminth infection alters humoral responses to H. pylori and serum pepsinogen I\/II ratio","volume":"7","author":"Du Y","year":"2005","journal-title":"Microbes Infect"},{"key":"e_1_2_6_159_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1224"},{"key":"e_1_2_6_160_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1485"},{"key":"e_1_2_6_161_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.523-531.2005"},{"key":"e_1_2_6_162_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02177.x"},{"key":"e_1_2_6_163_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3104"},{"key":"e_1_2_6_164_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363645"},{"key":"e_1_2_6_165_2","first-page":"G559","article-title":"Secretagogue\u2010specific effects of interleukin\u20101 on gastric acid secretion","volume":"261","author":"Wallace JL","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_6_166_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_2_6_167_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28000"},{"key":"e_1_2_6_168_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.12.1684"},{"key":"e_1_2_6_169_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01826.x"},{"key":"e_1_2_6_170_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20718"},{"key":"e_1_2_6_171_2","doi-asserted-by":"publisher","DOI":"10.1086\/376458"},{"key":"e_1_2_6_172_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34156"},{"key":"e_1_2_6_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00899-0"},{"key":"e_1_2_6_174_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00157-4"},{"key":"e_1_2_6_175_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033050"},{"key":"e_1_2_6_176_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.22.1680"},{"key":"e_1_2_6_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.01.007"},{"key":"e_1_2_6_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.10.001"},{"key":"e_1_2_6_179_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3658"},{"key":"e_1_2_6_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70090-3"},{"key":"e_1_2_6_181_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3511"},{"key":"e_1_2_6_182_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1488"},{"key":"e_1_2_6_183_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00266-X"},{"key":"e_1_2_6_184_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34751"},{"key":"e_1_2_6_185_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.3.419"},{"key":"e_1_2_6_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70200-8"},{"key":"e_1_2_6_187_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.5.619"},{"key":"e_1_2_6_188_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850170865"},{"key":"e_1_2_6_189_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.6.2031-2040.1996"},{"key":"e_1_2_6_190_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01281-X"},{"key":"e_1_2_6_191_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21187"},{"key":"e_1_2_6_192_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030530"},{"key":"e_1_2_6_193_2","doi-asserted-by":"publisher","DOI":"10.1086\/344321"},{"key":"e_1_2_6_194_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00189.x"},{"key":"e_1_2_6_195_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.5.639"},{"key":"e_1_2_6_196_2","first-page":"696","article-title":"Germ\u2010line p53\u2010targeted disruption inhibits Helicobacter\u2010induced premalignant lesions and invasive gastric carcinoma through down\u2010regulation of Th1 proinflammatory responses","volume":"62","author":"Fox JG","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_197_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5285.259"},{"key":"e_1_2_6_198_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203504"},{"key":"e_1_2_6_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00690-6"},{"key":"e_1_2_6_200_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1617"},{"key":"e_1_2_6_201_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm763"},{"key":"e_1_2_6_202_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1260605"},{"key":"e_1_2_6_203_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600170"},{"key":"e_1_2_6_204_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70496-8"},{"key":"e_1_2_6_205_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00324.x"},{"key":"e_1_2_6_206_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"},{"key":"e_1_2_6_207_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.066"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1868","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:51:56Z","timestamp":1761047516000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,17]]},"references-count":206,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/path.1868"],"URL":"https:\/\/doi.org\/10.1002\/path.1868","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.14101956.15575056","asserted-by":"object"}]},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,17]]},"assertion":[{"value":"2005-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}