{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:09:08Z","timestamp":1776445748120,"version":"3.51.2"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many autoimmune diseases including rheumatoid arthritis (RA), Sj\u00f6gren's syndrome (SS) and systemic lupus erythematosus (SLE) occur much more frequently in women than in men. There is much evidence that oestrogen is the major cause of this gender difference. Interestingly, oestrogen relieves the symptoms of RA and SS but it exacerbates SLE. This contradictory effect of oestrogen on autoimmune diseases is not well understood. Most of the effects of oestrogen are mediated by two receptors: oestrogen receptor \u03b1 and \u03b2 (ER\u03b1 and ER\u03b2). To determine whether these contradictory effects of oestrogen relate to the involvement of distinct effects of the two ERs, we investigated expression of ER\u03b1 and ER\u03b2 in human secondary lymphoid tissues. We observed that, in tonsils, ER\u03b2 is expressed in lymphocytes of germinal centres (GC) and the follicular mantle zone as well as in granulocytes, while ER\u03b1 is expressed only in activated germinal centres but not in the follicular zone. ER\u03b2 is the predominant ER in human leucocytes from peripheral blood, spleen and in leucocytes infiltrating cancers in both males and females. In addition, in different human lymphoma cell lines including Hodgkin lymphoma, Burkitt lymphoma, and multiple myeloma, ER\u03b2 is abundant while ER\u03b1 is not detectable. Our results indicate that ER\u03b2 is the predominant type of ER in mature lymphocytes. We suggest that ER\u03b1 and ER\u03b2 have distinct roles in secondary lymphoid tissues and that further studies with ER\u03b2\u2010specific agonists will help to elucidate the role of ER\u03b2 in these tissues. Copyright \u00a9 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1883","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T08:16:27Z","timestamp":1132301787000},"page":"408-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Differential expression of oestrogen receptors in human secondary lymphoid tissues"],"prefix":"10.1002","volume":"208","author":[{"given":"Gil\u2010Jin","family":"Shim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Gherman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Omoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Bouton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lor\u00e1nd Levente","family":"Kis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Thulin","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010\u00c5ke","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0901-777"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90173-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.6.1230"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1331\/108658002763029599"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1990.tb03311.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405099101"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307915100"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0731830100"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.2059"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/90659"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.7.2309"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01599.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.1.27"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.0105.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80637-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/416865a"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111150898"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.1.337"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.10.007"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00762.x"},{"key":"e_1_2_6_22_2","first-page":"1305","article-title":"Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells","volume":"25","author":"Suenaga R","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.011513098"},{"key":"e_1_2_6_24_2","first-page":"253","article-title":"Thymic involution in pregnant mice. II. Functional aspects of the remaining thymocytes","volume":"44","author":"Phuc LH","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1998.1372"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.1999.18.377"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.114"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214873"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05914"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1003"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/153685904322771971"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009065836"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63490-6"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1886"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6936"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4802"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63257-9"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.4.2435"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1159\/000048757"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171460798"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH689>3.0.CO;2-A"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01212.x"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.1883","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.1883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:04:45Z","timestamp":1761044685000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.1883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,18]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1002\/path.1883"],"URL":"https:\/\/doi.org\/10.1002\/path.1883","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,18]]},"assertion":[{"value":"2005-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}