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The C\u2010type lectin, DC\u2010SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC\u2010SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV\u2010positive and HIV\u2010negative patients. Moreover, we demonstrate that DC\u2010SIGN can act as an entry receptor for ML, as it does for <jats:italic>M. tuberculosis<\/jats:italic>, through the cell wall component lipoarabinomannan. DC\u2010SIGN is expressed on virtually all ML\u2010containing cells, providing further evidence for its role as a receptor. DC\u2010SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells. Copyright \u00a9 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.1972","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T09:48:00Z","timestamp":1143798480000},"page":"182-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["DC\u2010SIGN association with the Th2 environment of lepromatous lesions: cause or effect?"],"prefix":"10.1002","volume":"209","author":[{"given":"EJ","family":"Soilleux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EN","family":"Sarno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MO","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Moseley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Horsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UG","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SL","family":"Vowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RJ","family":"Shattock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EP","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80443-2"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12381958"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.3.445"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1344"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4265"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2003.11107803.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.1186"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1635"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200310029"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200586200"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021468"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2637"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1246"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:VIRU.0000012260.32578.72"},{"issue":"3","key":"e_1_2_6_16_2","first-page":"255","article-title":"Classification of leprosy according to immunity. 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