{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:58:24Z","timestamp":1788173904461,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Previous studies have suggested that amplification of genes, notably the\n                    <jats:italic>TOP2A<\/jats:italic>\n                    gene, on chromosome arm 17q may be important for the development of malignant peripheral nerve sheath tumour (MPNST). In order to study the frequency, distribution, and chromosomal organization of rearrangements at 17q, interphase and metaphase fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) were used to evaluate copy number changes at 17q in 28 MPNSTs. Increased copy numbers were seen for the\n                    <jats:italic>ERBB2<\/jats:italic>\n                    and\n                    <jats:italic>TOP2A<\/jats:italic>\n                    genes in eight and nine cases, respectively, supporting a potential role for these two genes in MPNST tumourigenesis. Net gain of distal 17q material was observed in 16 of the 28 MPNSTs, with high\u2010level gain in three cases, and was associated with poor outcome. Among the 26 patients for whom follow\u2010up data were available, gain of distal 17q was present in 11 of 12 tumours that had metastasized, compared with 4 of 14 of those that had not metastasized. Detailed FISH mapping analysis of metaphase spreads identified a 2 Mb commonly gained\/amplified region at 17q25. Among the genes mapping to this region,\n                    <jats:italic>BIRC5<\/jats:italic>\n                    , which encodes the baculoviral IAP repeat\u2010containing protein 5\/survivin protein, is a strong candidate target gene for amplification, as it has been previously shown to be overexpressed in neurofibromatosis type 1\u2010associated MPNST. Three other genes that co\u2010amplified with\n                    <jats:italic>BIRC5<\/jats:italic>\n                    represent other potential candidate genes:\n                    <jats:italic>PTDSR<\/jats:italic>\n                    involved in apoptosis;\n                    <jats:italic>SEPT9<\/jats:italic>\n                    overexpressed in human malignant brain tumours; and\n                    <jats:italic>SOCS3<\/jats:italic>\n                    involved in cell survival and differentiation of neurons. Copyright \u00a9 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.1998","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T10:58:27Z","timestamp":1148381907000},"page":"492-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Identification of a novel amplicon at distal 17q containing the\n                    <i>BIRC5\/SURVIVIN<\/i>\n                    gene in malignant peripheral nerve sheath 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