{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:53:44Z","timestamp":1791118424397,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T00:00:00Z","timestamp":1156118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Cancer Foundation;","award":["70-313-R\u00fcl"],"award-info":[{"award-number":["70-313-R\u00fcl"]}]},{"name":"Hungarian-German Intergovernmental Science and Technology Cooperation Programme;","award":["OTKA-T 046663 KON"],"award-info":[{"award-number":["OTKA-T 046663 KON"]}]},{"name":"Alexander von Humboldt Foundation;","award":["OTKA-T 046663 KON"],"award-info":[{"award-number":["OTKA-T 046663 KON"]}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"crossref","award":["OTKA-T 046663 KON"],"award-info":[{"award-number":["OTKA-T 046663 KON"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010cell lymphomas (PTCL) have not been successfully correlated with specific developmental stages of reactive T\u2010cells. Mature T\u2010cells pass through distinct stages upon antigen encounter. Na\u00efve T\u2010cells are CD45RA<jats:sup>+<\/jats:sup>\/CD45R0<jats:sup>\u2212<\/jats:sup>\/CD27<jats:sup>+<\/jats:sup>\/CCR7<jats:sup>+<\/jats:sup>. After antigen contact they replace CD45RA expression with CD45R0. The mature T\u2010cells differentiate to central memory cells, which retain CD27 and CCR7, or to effector memory cells, which lose expression of both molecules depending on the strength of the antigen interaction. In this study, we evaluated lymph node biopsies from eight PTCL\u2014not otherwise specified (PTCL\u2010NOS), seven angioimmunoblastic T\u2010cell lymphomas (AILT), and 15 anaplastic large cell lymphomas (ALCL). Detection of tumour cells with antibodies that recognize specific rearranged T\u2010cell receptor V\u03b2 segments allowed us to investigate the expression of various differentiation\u2010associated molecules. Results were analysed by hierarchical cluster analysis. All AILT and ALCL showed a homogeneous effector cell phenotype (CD45RA<jats:sup>\u2212<\/jats:sup>\/CD45R0<jats:sup>+<\/jats:sup>\/CD27<jats:sup>\u2212<\/jats:sup>), but differed in the cytotoxic and activation markers expressed. Several (5\/8) PTCL\u2010NOS clustered together; these cases all exhibited a CD4<jats:sup>+<\/jats:sup> central memory cell phenotype (CD45RA<jats:sup>\u2212<\/jats:sup>\/CD45R0<jats:sup>+<\/jats:sup>\/CD27<jats:sup>+<\/jats:sup>) and four expressed the lymph node homing receptor CCR7. In conclusion, AILT and ALCL tumour cells correspond to different subsets of effector cells, while a subset of PTCL\u2010NOS correlates with a non\u2010effector T\u2010cell population. Copyright \u00a9 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2046","type":"journal-article","created":{"date-parts":[[2006,8,21]],"date-time":"2006-08-21T08:52:07Z","timestamp":1156150327000},"page":"172-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Nodal peripheral T\u2010cell lymphomas correspond to distinct mature T\u2010cell populations"],"prefix":"10.1002","volume":"210","author":[{"given":"E","family":"Geissinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Bonzheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kren\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Reimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HK","family":"M\u00fcller\u2010Hermelink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"R\u00fcdiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.17717.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.593"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.381"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.4.1053"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.04.010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0200184"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/360264a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220418"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.5.2426"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.7.1027"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1407"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.11.5538"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.11.6675"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.297"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199910000-00003"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10758"},{"key":"e_1_2_6_21_2","first-page":"313","article-title":"Perforin and granzyme expression in cytotoxic T\u2010cell lymphomas","volume":"11","author":"Yamashita Y","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60576-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1037"},{"key":"e_1_2_6_24_2","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14863"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.10.4005.bloodjournal88104005"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64287-3"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097644"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.2.685"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.10.3487.410k39_3487_3493"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1309\/J3CTLTTJEVUY4YL0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1309\/RF4PVCEGGN2XAF86"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1077-2"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-379"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00022.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2000.00121.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-57276-0_21"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040774"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1352"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0371"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209178"},{"key":"e_1_2_6_42_2","first-page":"605","article-title":"Classification of distinct subtypes of peripheral T\u2010cell lymphoma unspecified, identified by chemokine and chemokine receptor expression: analysis of prognosis","volume":"25","author":"Ohshima K","year":"2004","journal-title":"Int J Oncol"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.05.008"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1083"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90553-4"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf033"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0269"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70213-8"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0146"},{"key":"e_1_2_6_50_2","article-title":"Peripheral T\u2010cell lymphoma gene expression profiles","author":"Martinez\u2010Delgado B","journal-title":"Hematol Oncol"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3513.bloodjournal8893513"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01444-9"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1309\/HEFL7KC435KFWEX8"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2004.07.006"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05313.x"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00051.x"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.2046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.2046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.2046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:40:55Z","timestamp":1761061255000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.2046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,21]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1002\/path.2046"],"URL":"https:\/\/doi.org\/10.1002\/path.2046","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,21]]},"assertion":[{"value":"2006-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}