{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:22:42Z","timestamp":1792304562373,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T00:00:00Z","timestamp":1163030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serous borderline tumours (SBTs) of the ovary were originally classified as such because the vast majority behave in a remarkably indolent manner, even in the presence of widespread tumour deposits, termed implants, and\/or lymph node involvement. The pathogenesis of the implants is currently unknown. Two major hypotheses have been proposed: the first favours a monoclonal origin, arguing that the peritoneal lesions derive from neoplastic cells that are shed from the primary ovarian tumour. The second hypothesis favours a polyclonal origin as a result of a field defect of susceptible M\u00fcllerian cells from which multiple independent tumours arise. To test both hypotheses, genome\u2010wide allelotyping and <jats:italic>B\u2010RAF\/K\u2010RAS<\/jats:italic> mutation analyses were employed to assess clonality in 25 metachronous or synchronous tumours from ten SBT patients. Loss of heterozygosity (LOH) profiling and <jats:italic>K\u2010RAS\/B\u2010RAF<\/jats:italic> mutation analysis showed concordance of the genetic changes in all sites in 21 tumours from eight patients who were informative. These results favour a common origin, underscored by a likelihood ratio (probability of common origin\/probability of independent origin) ranging from 2.43 to 7 662 850. In conclusion, this study strongly supports the hypothesis that both non\u2010invasive and invasive implants arise as a consequence of spread from a single ovarian site. Copyright \u00a9 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2074","type":"journal-article","created":{"date-parts":[[2006,11,9]],"date-time":"2006-11-09T10:46:55Z","timestamp":1163069215000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Clonal analysis favours a monoclonal origin for serous borderline tumours with peritoneal implants"],"prefix":"10.1002","volume":"210","author":[{"given":"NL","family":"Sieben","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GMJM","family":"Roemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Oosting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GJ","family":"Fleuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"van Engeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,9]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"117","volume-title":"Pathology and Genetics of Tumours of the Breast and Female Genital Organs","author":"Lee KR","year":"2003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200209000-00002"},{"key":"e_1_2_6_4_2","first-page":"83","volume-title":"Pathology of the Ovary","author":"Prat J","year":"2004"},{"key":"e_1_2_6_5_2","first-page":"2328","article-title":"Evidence for the multifocal origin of bilateral and advanced human serous borderline ovarian tumors","volume":"58","author":"Lu KH","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.15.1147"},{"key":"e_1_2_6_7_2","first-page":"56","article-title":"Microdissection based mutational genotyping of serous borderline tumors of the ovary","volume":"24","author":"Krishnamurti U","year":"2005","journal-title":"Int J Gynecol Pathol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000056994.81259.32"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1521"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63906-5"},{"key":"e_1_2_6_11_2","first-page":"714","article-title":"Molecular genetic evidence for monoclonal origin of bilateral ovarian serous borderline tumors. Erratum","volume":"168","author":"Sieben NLG","year":"2006","journal-title":"Am J Pathol"},{"key":"e_1_2_6_12_2","first-page":"388","article-title":"Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction","volume":"44","author":"Weber JL","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80013-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg009"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.6.484"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1736"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00002"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.2074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.2074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:41:42Z","timestamp":1761061302000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.2074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,9]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/path.2074"],"URL":"https:\/\/doi.org\/10.1002\/path.2074","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,9]]},"assertion":[{"value":"2006-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}