{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:49Z","timestamp":1786978429690,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The pathogenetic relationship of marginal zone B\u2010cell lymphoma (MALT lymphoma) of the gastrointestinal (GI) tract and eventually co\u2010existing aggressive B\u2010cell lymphoma and primary aggressive B\u2010cell lymphoma remains to be elucidated. The RNA of laser\u2010microdissected cells was isolated and amplified from small and\/or large cell compartments of eight MALT lymphomas (small cell lymphoma, SCL), 14 GI diffuse large B\u2010cell lymphomas (large cell lymphoma, LCL), and ten GI B\u2010cell lymphomas with composite small and large cell compartments (ComL) and expression analyses were performed using cDNA arrays. Hierarchical cluster analysis clearly separated SCL and LCL and the small and large cell compartments of ComL. Likewise, cluster analysis with all samples of SCL, LCL, and ComL yielded two main \u2018small cell\u2019 and \u2018large cell\u2019 branches. Furthermore, 60 genes were differentially expressed between SCL and LCL, and 82 genes between the small and large cell components of ComL; 26 genes were discriminators in both settings. Use of the profiles of ComL as training sets for class prediction resulted in 95% accuracy for the classification of SCL and LCL. Collectively, the data strongly suggest that both secondary and primary aggressive B\u2010cell lymphomas of the GI tract are blastic marginal zone lymphomas. Copyright \u00a9 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2096","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T08:17:11Z","timestamp":1165393031000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Transcriptional profiling suggests that secondary and primary large B\u2010cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma"],"prefix":"10.1002","volume":"211","author":[{"given":"TFE","family":"Barth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HA","family":"Kestler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Michl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Weniger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Buchholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Gress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1409"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2001.1.241"},{"key":"e_1_2_7_5_2","first-page":"1153","article-title":"Relationship between high\u2010grade lymphoma and low\u2010grade B\u2010cell mucosa\u2010associated lymphoid tissue lymphoma (MALToma) of the stomach","volume":"136","author":"Chan JK","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.5450786.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803193381205"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780308"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280100504"},{"key":"e_1_2_7_10_2","first-page":"S126","article-title":"What are the criteria for distinguishing MALT from non\u2010MALT lymphoma at extranodal sites?","volume":"111","author":"Harris NL","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200013"},{"key":"e_1_2_7_12_2","volume-title":"Pathology and Genetics of Tumors of the Haematopoietic and Lymphoid Tissue","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008396618983"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1150"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.11.4321"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14863"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091062498"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"e_1_2_7_19_2","unstructured":"Holger Schwender2006;siggenes: SAM and Efron's Empirical Bayes ApproachesR Package Version 1.6.0. url:http:www.bioconductor.org."},{"key":"e_1_2_7_20_2","unstructured":"R: A Language and Environment for Statistical Computing[computer program]. 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