{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:18Z","timestamp":1786978278417,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T00:00:00Z","timestamp":1166054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We recently reported that low\u2010grade\n                    <jats:styled-content>m<\/jats:styled-content>\n                    ucosa\u2010\n                    <jats:styled-content>a<\/jats:styled-content>\n                    ssociated\n                    <jats:styled-content>l<\/jats:styled-content>\n                    ymphoid\n                    <jats:styled-content>t<\/jats:styled-content>\n                    issue lymphoma (MALToma) and diffuse large B\u2010cell lymphoma (DLBCL) with MALToma (DLBCL[MALT]) of stomach are equally responsive to\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication therapy (HPET) and that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010independent status is closely associated with nuclear translocation of BCL10. However, co\u2010existing MALToma and DLBCL components of gastric DLBCL(MALT) may respond differentially to HPET and the underlying mechanism remains unclear. Tumour tissue samples from 18 patients with microdissectable co\u2010existing MALToma and DLBCL cells were studied. The clonality of lymphoma cells was examined by polymerase chain reaction\u2010based amplification of the CDR3 region of the\n                    <jats:italic>IgH<\/jats:italic>\n                    gene and confirmed by DNA sequence analysis. BCL10 expression was determined by immunohistochemistry. Differential response of co\u2010existing MALToma and DLBCL to HPET was defined as complete eradication of one component while the other component remained. Five (27.8%) of the 18 patients showed different\n                    <jats:italic>IgH<\/jats:italic>\n                    gene rearrangements in the two components and three (60%) of these five patients had differential response of MALToma and DLBCL to HPET. By contrast, 13 patients showed identical\n                    <jats:italic>IgH<\/jats:italic>\n                    gene rearrangements and only one (8%) of them had differential response of the two components to HPET (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.044). Further, all four patients with differential response of MALToma and DLBCL to HPET showed nuclear expression of BCL10 in the\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010independent component and cytoplasmic expression of BCL10 in the\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010dependent component while the expression patterns of BCL10 were identical in both of these components in the 14 patients who had similar tumour response to HPET. We conclude that different clonality is a common reason for the differential response of co\u2010existing MALToma and DLBCL of gastric DLBCL(MALT) to HPET and that immunohistochemical examination of BCL10 expression may help to identify the co\u2010existence of these components. Copyright \u00a9 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.2117","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T07:47:37Z","timestamp":1166082457000},"page":"296-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Differential response to\n                    <i>H. pylori<\/i>\n                    eradication therapy of co\u2010existing diffuse large B\u2010cell lymphoma and MALT lymphoma of stomach\u2014significance of tumour cell clonality and BCL10 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